氟宁抗氟作用机制的初步研究

The mechanism study of Funing antagonizing fluorosis function

目的 探讨氟宁抗氟的作用机制。方法 采用随机分组 ,A组为氟宁组 ,B组为试验对照组 ,C组为空白对照组 ,观察各组动物血、尿、粪、器官组织的含氟量及血清酶活性变化。结果 A组骨、牙齿中含氟量显著低于 B组 (P <0 .0 5 ) ,血和尿含氟量显著高于 B组 (P <0 .0 5 ) ,碱性磷酸酶 (AKP)及肌酸磷酸激酶 (CPK )活性显著低于 B组 (P <0 .0 5 )。结论 氟宁可促进氟的排泄 ,减少氟在组织中的沉积 ,具有明显的抗氟作用。

Objective To probe into the mechanism of Funing antagonizing fluorosis function.Methods Animals were classified randomly into three groups:group A were given Funing.group B was experiment control group and group C was blank control group.After treated by a respective process,we tested the fluorine in the animals blood,urine dung and organ,and the vary of serumase.Results Fluorine content in bone and tooth of group A was notable lower than that of group B (P<0.05) and more in blood and urine than group B.AKP and CPK was lower than group B too.Conclusions Funing can promote the excreting of florine and reduce its depositing in organs,so it is effective to antagonizing fluorosis.