慢性氟中毒大鼠血脂及载脂蛋白的变化

Observation on change of lipidemia and lipoprotein in wistar rats with fluorosis

目的 观察慢性氟中毒大鼠血脂及载脂蛋白变化。方法 给大鼠饮用高氟水半年致慢性氟中毒 ,测定血清中总胆固醇 (TC)、甘油三脂 (TG)、高密度脂蛋白胆固醇 (HDL - c)、低密度脂蛋白胆固醇 (L DL - c)、载脂蛋白 AI(APO AI)、载脂蛋白 B(APO B)及动脉硬化指数 (AI)、冠心指数 (R- CHD)。结果 实验组血清中 TC、TG、HDL- c、L DL- c、A PO AI、APO B及 AI、R- CHD均高于对照组 ,差异有显著意义 (P <0 .0 5 )。结论 慢性氟中毒大鼠血脂及载脂蛋白呈异常升高变化 。

Objective To observe the change of lipidemia and lipoprotein in wistar rats with fluorosis.Methods 14 wistar rats were fed normal food with hyper concentration of NaF water (100 mg/L) for six months,the TC,TG,HDL c,LDL c,APO A I APO B and AI,R CHE were measured in serum.Results The result show that there are an increace of TC,TG,HDL c,LDL c,APO A I,APO B and AI,R CHD compared with normal rats (P<0.05).Conclusions The result indicate that the fluorosis can increase the lipidemia and lipoprotein in rats with fluorosis and lead to atheroselerosis.