摘要
目的探讨宫颈癌患者Th17细胞相关因子与25-羟基维生素D检测的临床价值。方法收集宫颈癌患者68例,其中腺癌28例、鳞状细胞癌40例,选取年龄与其相匹配的50例健康体检者作为对照组。分析25羟维生素D与白介素17(IL-17)、白介素6(IL-6)在各组间的差异及其相关性。结果宫颈癌患者血浆25-羟基维生素D浓度为(24.50±6.80)ng/ml,低于健康对照组(35.10±8.70)ng/ml,宫颈癌患者血浆IL-17浓度为550(350,705)ng/L,IL-6浓度为480(390,620)ng/L,均低于健康对照组,差异有统计学意义(P均<0.05);腺癌患者血浆25-羟基维生素D、IL-17、IL-6浓度与鳞状细胞癌患者比较,差异无统计学意义(P>0.05);宫颈癌患者血浆IL-6、IL-17与25-羟基维生素D存在相关性(r分别=0.37、0.40,P均<0.05)。结论宫颈癌患者血浆25-羟基维生素D与Th17细胞相关因子浓度检测对治疗和预后监测具有一定临床价值。
Objective To investigate plasma T helper cell 17 cytokine and 25 （OH） vitamin D in patients with cervical cancer and its clinical value. Methods Sixty eight cases with cervical cancer were enrolled, including 28 cases of adeno-carcinoma, 40 cases squamous cell carcinoma. Selected age matched 50 healthy volunteers as a control group. 25（OH） vitamin D and T helper cell 17 cytokine in the differences among the groups and their correlation were analyzed. Results Cervical cancer patients plasma 25（OH） vitamin D concentration were（24.50±6.80）ng/ml, lower than the healthy control group （35.10 ±8.70） ng/ml, cervical cancer patients plasma IL-17, IL-6 concentrations were 550 （350,705）ng/L,480 （390,620）ng/L, lower than the healthy control group, the difference was statistically significant（P〈0.05）; adenocarcinoma patients plasma 25（OH） vitamin D, IL-17, IL-6 concentrations was not statistically significant difference with patients of squamous cell carcinoma （P〉0.05）, there was correlation of plasma IL-17, IL-6 and 25 （OH） vitamin D in patients with cervical cancer （r=0.37, 0.40, P〈0.05）. Conclusions Plasma 25 （OH） vitamin D and IL-17, IL-6 concentration detection are helpful for monitoring the treatment and prognosis of patients with cervical cancer.
出处
《全科医学临床与教育》
2014年第3期263-265,共3页
Clinical Education of General Practice
