后程加速超分割放射治疗食管癌疗效荟萃分析

Meta-analysis of the effect of late course accelerated hyperfractionation radiotherapy for esophageal carcinoma

目的 评价后程加速超分割放射治疗食管癌疗效。方法 对 6个后程加速超分割放射治疗食管癌临床试验进行Meta分析。结果 采用固定效应模型计算 ,后超组 1、3年生存率分别是常规组的 2 .39(1.5 8～ 3.6 2 )、3 .0 5 (1.96～ 4.74)倍 ;采用随机效应模型计算 ,后超组 1、3年生存率分别是常规组的 2 .43(1.5 4～ 3.82 )、2 .99(2 .0 8～ 4.30 )倍。结论 后程加速超分割放射治疗食管癌优于常规分割放射治疗 。

Objective To evaluate the effect of late course accelerated hyperfractionation radiotherapy(LCAHR) for esophageal carcinoma. Methods Six clinical trials on LCAHR for esophageal carcinoma were reviewed by means of Meta analysis . Results The 1 and 3 year survival rates in the LCAHR group derived from the fixed effect model were 2.39 (1.58～3.62) and 3.05(1.96～4.74) times higher than the conventional fractionation group. With the random effect model,the 1 and 3 year survival rates in the LCAHR group were 2.43(1.54～3.82) and 2.99(2.08～4.30) times higher than the conventional fractionation group.Conclusion For esophageal carcinoma,the better outcome of LCAHR makes it advisable in extensive clinical practice.