云南不同海拔不同民族糖尿病患者血糖和糖化血红蛋白的比较

Blood glucose and glycosylated hemoglobin levels of type 2 diabetes at different altitudes and different races in Yunnan Province

目的 探讨海拔、民族、性别及年龄对血糖和糖化血红蛋白的影响.方法 分别在云南省的昆明、丽江、景洪三个不同海拔地区选择居住在本市＞5年,糖尿病病程＞半年,降糖治疗＞3个月未做调整的2型糖尿病患者410例,比较不同海拔、不同民族、不同性别及年龄糖尿病患者之间空腹血糖（FBG）、餐后2h血糖（2 h PBG）、血红蛋白（Hb）及糖化血红蛋白（HbA1c）水平,对民族与HbA1c进行单因素相关分析.结果 不同海拔、不同民族、不同性别及不同年龄的2型糖尿病患者之间FBG（P=0.49,P=0.1,P=0.09,P=0.3）、2 h PBG（P=0.33,P=0.4,P=0.7,P=0.1）和HbA1c（P=0.47,P =0.28,P=0.2,P=0.07）差异均无统计学意义,但Hb差异有统计学意义（P＜0.01）,民族与HbA1c之间无明显相关（r =0.003,P=0.6）.结论 海拔、民族、性别及年龄对2型糖尿病患者Hb有影响,但对血糖和HbA1c无明显影响.

Objective To investigate the effects of altitude,race,gender and age on blood glucose and glycosylated hemoglobin（HbA1 c） of type 2 diabetes.Methods A total of 410 patients with type 2 diabetes （T2DM） who resided at different altitudes in Jinghong,Kunming and Lijiang city for over 5 years and received antidiabetic treatment without adjustments for over 3 months were enrolled.To compare blood glucose,hemoglobin （Hb） and HbA1 c levels of T2DM among different altitudes,different races,different genders and different ages,The correlation between races and HbA1c was evaluated with Pearson＇s correlation analysis.Results No significant differences were observed in fasting blood glucose （FBG） （P =0.49,P =0.1,P =0.09,P =0.3）,2 h postprandial blood glucose （2 h PBG） （P =0.33,P =0.4,P =0.7,P =0.1）,and HbA1 c （P =0.47,P =0.28,P =0.2,P =0.07） levels between patients at different altitudes,different races,different genders and different ages.However,there were significant differences in Hb （P 〈0.01）.There was no significant correlation between races and HbA1c levels（r =0.003,P =0.6）.Conclusions There were effects of altitude,race,gender and age on hemoglobin of type 2 diabetes,but no effects on glycosylated hemoglobin.