胰岛β细胞容量减少的早期生物学标志研究进展
摘要
血糖的调节是机体葡萄糖稳态维持中十分重要的环节.胰岛β细胞容量减少会引起机体胰岛素分泌不足,进而导致葡萄糖稳态失衡,在糖尿病的发生发展中起着重要的作用.糖尿病的发展非常隐匿,Meier等^[1]最新研究显示,当确诊糖尿病前期和糖尿病时,β细胞容量实际已分别下降21％及64％.
出处
《中华糖尿病杂志》
CAS
CSCD
2014年第5期335-339,共5页
CHINESE JOURNAL OF DIABETES MELLITUS
基金
上海市科技创新重点项目（11140900900）
上海交通大学医学院博士创新基金（BXJ201236）
参考文献29
-
1Meier JJ, Breuer TG, Bonadonna RC, et al. Pancreatic diabetes manifests when beta cell area declines by approximately 65 % in humans[J]. Diabetologia ,2012,55 : 1346-1354.
-
2Gerstein HC, Santaguida P, Raina P, et al. Annual incidence and relative risk of diabetes in people with various categories of dysglycemia : a systematic overview and meta-analysis of prospective studies [ J]. Diabetes Res Clin Pract, 2007,78 : 305- 312.
-
3Rahier J, Guiot Y, Goebbels RM, et al. Pancreatic βcell mass in European subjects with type 2 diabetes [ J ] . Diabetes Obes Metab ,2008,10 Suppl 4 : S32-42.
-
4Saisho Y, Butler AE, Manesso E, et al. β-Cell mass and turnover in humans: effects of obesity and aging[ J]. Diabetes Care,2013, 36:111-117.
-
5Neutzsky-Wulff AV, Andreassen KV, Hjuler ST, et al. Future detection and monitoring of diabetes may entail analysis of both beta-cell function and volume: how markers of beta-cell loss may assist[ J]. J Transl Med,2012,10:214.
-
6Montane J, Klimek-Abercrombie A, Potter K J, et al. Metabolic stress, IAPP and islet amyloid[ J]. Diabetes Obes Metab,2012, 14 Suppl 3 :S68-77.
-
7Holst JJ, Deacon CF, Vilsbll T, et al. Glucagon-like peptide-1, glucose homeostasis and diabetes[ J]. Trends Mol Med ,2008,14 : 161-168.
-
8Mosedale M, Egodage S, Calma RC, et al. Neurexin-1 alphacontributes to insulin-containing secretory granule docking [ J ]. J Biol Chem ,2012,287:6350-6361.
-
9Suckow AT, Comoletti D, Waldrop MA, et al. Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion [ J]. Endocrinology, 2008,149:6006-6017.
-
10Sekiguchi Y, Owada J, Oishi H, et al. Noninvasive monitoring of β-cell mass and fetal β-cell genesis in mice using bioluminescence imaging[ J]. Exp Anim, 2012,61:445-451.
-
1李明,李倩.肝源性糖代谢稳态失衡178例临床分析[J].实用糖尿病杂志,2008,4(5):32-33. 被引量：3
-
2刘伟,黄玮.心肌梗死后内质网应激的研究及治疗进展[J].心血管病学进展,2014,35(2):224-226. 被引量：2
-
3王安宇,乔艺杰,魏良纲.溃疡微环境稳态失衡与糖尿病足[J].医学与哲学（B）,2010,31(12):45-46. 被引量：7
-
4于泽谋,龚涛.血管稳态对动脉粥样硬化发生发展影响的研究进展[J].国际神经病学神经外科学杂志,2016,43(4):346-349. 被引量：7
-
5王丽艳,赵明.银杏叶提取物对糖尿病患者外周血内皮祖细胞GPX及Caspase-3活性的影响[J].微循环学杂志,2012,22(3):17-20. 被引量：5
-
6朱敏,刘倩琦.内质网应激与糖尿病胰岛β细胞凋亡的研究进展[J].国际儿科学杂志,2007,34(5):376-379.
-
7孙向东,付丽琳.餐后高血糖的危害及其干预策略[J].实用糖尿病杂志,2008,4(5):4-6. 被引量：3
-
8朱启仁.糖尿病友慎用氟喹诺酮类药物[J].中华养生保健,2008(1):24-24.
-
9朱启仁.糖尿病友慎用氟喹诺酮类药物[J].家庭医学（上半月）,2006(13):45-45.
-
10朱启仁.糖尿病友慎用氟喹诺酮类药物[J].糖尿病天地（文摘刊）,2008(2):18-18.
