期刊文献+

内质网在神经细胞稳态中的作用 被引量:1

下载PDF
导出
摘要 内质网是真核细胞中重要的细胞器之一,是蛋白质加工和钙储存的主要场所。内质网不仅本身参与Ca2+平衡的调节,还通过与其它细胞器如线粒体相互作用,共同调节神经细胞的各种活动。此外,细胞在内质网应激状态下启动的未折叠蛋白反应,与氧化应激、自噬等细胞反应联系密切,在对抗应激、促进细胞生存或凋亡过程中发挥关键作用。本文就上述各方面对内质网在神经细胞稳态方面的作用作一综述。
出处 《国际神经病学神经外科学杂志》 2014年第2期164-168,共5页 Journal of International Neurology and Neurosurgery
基金 国家自然科学基金(81241037) 河北省自然科学基金(H2013307046)
  • 相关文献

参考文献36

  • 1Su J, Zhou L, Kong X, et al. Endoplasmic reticulum is at the crossroads of autophagy, inflammation, and apoptosis sig- naling pathways and participates in the pathogenesis of diabetes mellitus. J Diabetes Res, 2013, 2013: 193461.
  • 2Chakrabarti A, Chen AW, Varner JD. A review of the mam- malian unfolded protein response. Biotechnol Bioeng, 2011, 108(12) : 2777-2793.
  • 3Stetler RA, Gan Y, Zhang W, et al. Heat shock proteins: cellular and molecular mechanisms in the central nervous sys- tem. Prog Neurobiol, 2010, 92(2) : 184-211.
  • 4Chan SL, Fu W, Zhang P, et al. Herp stabilizes neuronal Ca2 + homeostasis and mitochondrial function during endoplas- mic reticulum stress. J Biol Chem, 2004, 279 (27): 28733 -28743.
  • 5Eletto D, Dersh D, Argon Y. GRP94 in ER quality control and stress responses. Semin Cell Dev Biol, 2010, 21 (5) : 479 -485.
  • 6Smaili SS, Pereira GJ, Costa MM, et al. The role of calci- um stores in apoptosis and autophagy. Curr Mol Med, 2013, 13(2) : 252-265.
  • 7Alberdi E, Wyssenbach A, Alberdi M, et al. Ca(2. ) -de- pendent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid beta-treated astrocytes and in a model of Alzheimer' s disease. Aging Cell, 2013 , 12 ( 2 ) : 292- 302.
  • 8Fu M, Li L, Albrecht T, et al. Autoerine motility factor/ phosphoglucose isomerase regulates ER stress and cell death through control of ER calcium release. Cell Death Differ, 2011, 18(6): 1057-1070.
  • 9Zherebitskaya E, Schapansky J, Akude E, et al. Sensory neurons derived from diabetic rats have diminished internal Ca2+ stores linked to impaired re-uptake by the endoplasmic reticulum. ASN Neuro, 2012,4(1).
  • 10Cardenas C, Miller RA, Smith I, et al. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2 + trans- fer to mitochondria. Cell, 2010, 142 (2) : 270-283.

二级参考文献24

  • 1Schapira AH. Targeting Mitoc'hondria for Neuroprotection inParkinson ' s Disease, Antioxid Redox Signal, 2012, 16 (9) : 965 -973.
  • 2Chu CT. Autophagic stress in neuronal injury and disease. J Neuropathol Exp Neurol, 2006, 65 (5) : 423-432.
  • 3Webb JL, Ravikumar B, Atkins J, et al. Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem, 2003, 278(27) : 25009-25013.
  • 4Geisler S, Holmstrom KM, Treis A, et al. The PINK 1 / Par- kin-mediated mitophagy is compromised by PD-associated mu- tations. Autophagy, 2010, 6(7) : 871-878.
  • 5Lynch-Day MA, Mao K, Wang K, et al. The role of auto- phagy in Parkinson' s disease. Cold Spring Harb Perspect Med, 2012, 2(4) : 258-262.
  • 6Kondo Y, Kondo S. Autophagy and cancer therapy. Autopa- hagy, 2006 , 2 (2) : 85 -90.
  • 7Liang XH, Jackson S, Seaman M, et al. Induction of autoph- agy and inhibition of tumorigenesis by beclinl. Nature, 1999, 402(6762) : 672-676.
  • 8Shintani T, Klionsky DJ. Autophagy in health and disease : a double-edged sword. Science, 2004, 306 (5698) : 990-995.
  • 9Klionsky D J, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science, 2000 , 290 ( 5497 ) : 1717- 1721.
  • 10Cuervo AM, Dice JF. A receptor for the selective uptake and degradation of proteins by lysosomes. Science, 1996, 273 (5274) : 501-503.

共引文献4

同被引文献4

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部