抗病毒治疗在乙型肝炎相关性肝衰竭中的应用

Application of anti-hepatitis B virus therapy in liver failure

乙型肝炎病毒(HBV)在HBV相关性肝衰竭的发病过程中起重要作用,其发病机制主要为免疫活化机制,免疫抑制者体内则可见肝细胞的直接损伤。为此,抗病毒治疗的作用日益受到重视。近年来,有关抗病毒治疗的时机及药物选择成为研究热点,提倡应尽早、及时采用强效低耐药的核苷(酸)类似物(NUCs)治疗,同时注意长期治疗的药物安全性。优化治疗或初始联合治疗是目前两种主要策略。

Hepatitis B virus （HBV） plays an important role in the pathogenesis of HBV-related liver failure,the main pathogenesis of which is immune mechanism, and HBV can directly damage to liver cells in immunosuppressed patients. Therefore, the role of antiviral therapy is becoming more and more important. In recent years, the time of antiviral therapy and choices of drugs become research hotspots, and the timely and early adoption of potent and low-resistance nucleos （t）ide analogues （NUCs） is promoted. Meanwhile, attention should be paid to drug safety in long-term treatment. As a result, there are two main strategies-optimizing treatment or initial combination therapy.