改良电痉挛治疗与686项目结合治疗精神分裂症阳性症状

Integrated Therapy with Modified Electric Convulsive Therapy and 686 Project for Positive Symptoms of Schizophrenia

目的探讨改良电痉挛治疗(MECT)与686项目结合治疗精神分裂症阳性症状的临床疗效。方法将299例686项目精神分裂症患者随机分为两组,分别给予MECT与利培酮治疗8周。采用简明精神病评定量表(BPRS)、阳性症状量表(SAPS)、不良反应量表(TESS)评定疗效及不良反应。结果实验组治疗总有效率为91.33%,利培酮组为62.41%,两组比较差异有统计学意义(χ2=4.62,P<0.05)。实验组的锥体外系反应、窦速和停经泌乳等不良反应低于对照组(χ2=9.50,6.91,4.95;P<0.05)。结论 MECT与686项目结合治疗精神分裂症阳性症状安全有效。

Objective To explore the clinical effect of therapy of MECT and 686 project for schizophrenia. Methods A total of 299 schizophrenia patients of 686 project randomly divided into two groups were given a treatment of MECT and Risperidone for 8 weeks. The brief psychiatric rating scale（BPRS） , the positive syndrome scale（SAPS） and the Treatment Emergent Sympteol Scale（TESS） were used to evaluate the efficacy and adverse reaction. Results The total effectiveness of the study group was 91.33% ,while the control group 62.41%. The comparison difference of the two groups was statistically significant （ X2 = 4.62, P 〈 0.05 ）. Team of extrapyramidal reactions, sinus tachycardia and amenorrhea lactation syndrome adverse reaction were lower than the control group （X2 = 9.50,6.91,4.95 ;P 〈 0.05 ）. Conclusion The combined therapy of MECT and 686 project is safe and effective for positive symptoms of schizophrenia.