肠梗阻手术后以参附注射液治疗对患者白细胞介素-2 TNF-α以及T淋巴细胞亚群的影响

The Influence of Interleukin-2 TNF-α and T Lymphocyte Subsets of the Patients after Intestinal Obstruction Surgery Treated with Shenfu Injection

目的:研究肠梗阻手术后用参附注射液治疗对病患白细胞介素-2(IL-2),TNF-α以及T淋巴细胞亚群(T lymphocyte subsets,TLS)的影响。方法:从2012年2月到2013年2月,我院有96例病患行肠梗阻手术。以数字法随机分成观察组(48例)和对照组(48例)。对照组实施常规治疗,观察组则主要以参附注射液进行治疗。对比两组肠鸣音的恢复时间以及肛门排气时间,治疗前后TLS情况以及治疗前后IL-2及TNF-α情况。结果:观察组肠鸣音的恢复时间为61.1±14.4h,肛门排气时间为85.3±16.4h,显著少于对照组的73.7±13.4h,85.3±16.4h;观察组治疗之后CD4为30.90±7.18,CD4/CD8为1.11±0.24,均显著高于治疗之前的25.13±7.45,0.75±0.28,以及高于对照组治疗之后的27.11±4.81,0.72±0.18;观察组治疗之后CD8为30.42±5.61显著低于对照组治疗之后的39.38±6.77;观察组治疗之后IL-2水平为60.11±19.91 mg/L,显著高于治疗之前的35.68±21.33 mg/L,以及对照组治疗之后的44.08±17.76 mg/L。观察组治疗之后TNF-α水平显著低于治疗之前的56.75±6.20μg/L,以及对照组治疗之后的42.63±7.96μg/L;差异均有统计学意义(均P<0.05)。结论:肠梗阻术后以参附注射液实施治疗在明显促进病患恢复的同时,还可增加IL-2和CD4以及CD4/CD8,降低CD8和TNF-α水平,具有显著疗效,值得临床推荐。

Objective：To study the influence of interleukin -2, TNF-α and T lymphocyte subsets of the patients after intestinal obstruction surgery treated with Shenfu injection .Method：From February 2012 to February 2013, a total of 96 cases of patients needed intestinal obstruction surgery in our hospital .They were divided into the observation group （48 cases） and the control group （48 cases） according to digital random-ly.The control group was treated with conventional treatment , while the observation group was mainly treated with Shenfu injection , compared two groups of the recovery time of bowel sound , anal exhaust time and TLS , and IL-2 and TNF-αlevel before and after treatment .Result： The observation group ’ s recovery time of bowel sound was 61.1 ±14.4 hours, anal exhaust time was 85.3 ±16.4 hours, which were significantly less than those in control group of 73.7 ±13.4 hours, 85.3 ±16.4 hours; the observation group ’ s CD4 after treatment was 30.90 ±7.18, CD4/CD8 was 1.11 ±0.24, which were significantly higher than before treat-ment of 25.13 ±7.45, 0.75 ±0.28, and the control group after treatment of 27.11 ±4.81, 0.72 ±0.18;the observation group ’ s CD8 after treatment was 30.42 ±5.61 which were significantly lower than the control group after treatment of 39.38 ±6.77;the observation group ’ s IL-2 level after treatment was 60.11 ±19.91 mg /L, which was significantly higher than before treatment of 35.68 ±21.33 mg /L, and the control group after treatment of 44.08 ±17.76 mg /L.The observation group’s TNF-αlevel was 31.76±7.16μg/L,which was significantly lower than before treatment of 56.75 ±6.20μg /L, and the control group after treatment of 42.63 ±7.96μg /L;all the differences were statistically significant （all P ＆lt;0.05）.Conclusion： Patients with intestinal obstruction surgery using Shenfu injection can significantly promote the recovery , while also increase IL-2 and CD4, CD4/CD8, and reduce CD8, TNF-α, It＇s effective to,it is worthy of clinical rec-ommended.