摘要
介绍聚合物/药物配合体多药物传递系统、脂质体多药物传递系统、聚合物微胶束多药物传递系统等几类典型的多药物传递系统(multi-drug delivery system,MDDS).综述上述多药物传递系统在疾病的多药联合治疗及联合诊断、成像、治疗等领域的研究进展.以期为MDDS的设计及临床药物更有效的治疗提供参考,具有重要开发应用价值.
This paper introduced several typical multi-drug delivery systems (MDDS) including polymer/drug conjugates multi-drug delivery system, liposome multi-drug delivery system, polymer/micelle multi-drug delivery system etc. The research progress of above-mentioned typical MDDS in the field of multi-drug combination therapy and the combination of diagnosis, imaging and therapy were reviewed, he purpose of this article is to provide a reference for the design of MDDS and more effective clinical drug treatment. And the research of MDDS will undoubtedly have an important role in the fu- ture exploitation and applications.
出处
《华侨大学学报(自然科学版)》
CAS
北大核心
2014年第3期310-315,共6页
Journal of Huaqiao University(Natural Science)
基金
国家自然科学基金资助项目(31000441
31170939)
福建省自然科学基金资助项目(2013J01189)
福建省高等学校杰出青年科研人才培育计划(JA12004)
华侨大学中青年教师科研提升资助计划(ZQN-PY108)
关键词
联合治疗
药物传递系统
长效预后
协同增效
combination therapy
drug delivery system
long term prognosis
synergy