白细胞介素8基因多态性与新疆汉族迟发型阿尔茨海默病关系的研究

Relation between IL-8 gene polymorphism and delayed Alzheimer's disease in Xinjiang Han people

目的：探讨白细胞介素8（IL-8）基因-251A/T多态性与新疆汉族人群迟发性阿尔茨海默病（LOAD）遗传易感性的关系。方法选择老年患者80例为LOAD组，同期体检者80例为对照组。采用 PCR-RFLP检测IL-8基因-251A/T多态性分布。结果2组AA基因型分布及A等位基因频率比较，差异有统计学意义（16．3％ vs 7．5％， P＝0．035；41．3％ vs 27．5％，P＝0．010）。进一步分析显示，LOAD组A等位基因频率可能是LOAD的危险因素（OR＝1．851，95％ CI：1．159～2．957，P＝0．010）；AA基因型患LOAD的危险性是 TT 基因型的3．370倍（OR＝3.370，95％ CI：1．143～9．939，P＝0.023）；AT 基因型与 LOAD发病风险不相关（OR＝1．944，95％ CI：0．994～3.803，P＝0．051）。结论 IL-8基因-251A/T多态性与LOAD发病风险有一定关系。

Objective To study the relation between IL-8 gene-251A/T polymorphism and delayed Alzheimer＇s disease （AD）in Xinjiang Han people .Methods Eighty delayed AD patients served as a delayed AD group and 80 subjects undergoing physical examination served as a control group in this study .Distribution of IL-8 gene-251A/T polymorphism in two groups was detected by PCR-RFLP .Results The distribution of genotypes and alleles was different in two groups （P=0 .023 , P= 0 .010） .Further stratified analysis showed that the frequency of A allele was significantly higher in delayed AD group than in control group （OR= 1 .851 ,95% CI：1 .159 -2 .957 ,P=0.010） ,indicating that A allele is the risk factor for delayed AD .The frequency of AA genotype was significantly higher in delayed AD group than in control group （OR=3 .370 ,95% CI：1 .143-9.939 ,P=0 .023） ,indicating that the risk of delayed AD was 3 .370-fold higher in subjects with AA genotype than in those with TT genotype .The AT genotype was not related with the risk of delayed AD （OR=1 .944 ,95% CI：0 .994-3 .803 ,P=0 .051） .Conclusion IL-8 gene-251A/T pol-ymorphism is related with the risk of delayed AD .