双侧颈动脉内膜中层厚度差异与危险因素的相关性分析

Difference in bilateral carotid IMT and its relative risk factors

目的：探讨老年人双侧颈动脉内膜中层厚度（IMT）的差异及其与相关危险因素的相关性。方法整群抽样法调查山西省吕梁市4个地区常住居民1818例，并进行问卷调查、体格检查和彩色多普勒超声检查。根据年龄分为55～59岁组508例，60～64岁组476例，65～69岁组370例，70～74岁组238例，≥75岁组226例。应用多元线性回归法对双侧颈动脉IMT的影响因素进行分析。结果双侧颈动脉IMT随年龄增长而增厚。除65～69岁组外，55～59岁组、60～64岁组、70～74岁组和≥75岁组左侧颈动脉IMT明显较右侧厚[（0．72±0．11）mmvs（0.70±0．10）mm，（0．77±0．12）mmvs（0．75±0．12）mm；（0．83±0．13）mmvs（0．80±0．12）mm，（0．86±0．13）mmvs（0．82±0．14）mm，P＜0．05]。多元线性回归分析表明，年龄、吸烟指数、血压、即刻血糖、TC对左侧颈动脉IMT的影响大，而男性对右侧颈动脉IMT的影响较大。结论年龄在55岁以上人群，左侧颈动脉IMT较右侧厚，且双侧颈动脉IMT受年龄、性别、吸烟指数、血压、即刻血糖、TC影响不同。

Objective To study the difference in bilateral carotid IMT and its relative risk factors . Methods A total of 1818 permanent residents in 4 districts of Luliang City ,Shanxi Province , were investigated with questionnaire ,physical examination and by color Doppler ultrasonography . The subjects were divided into 55 -59 years old group （n= 508） ,60 -64 years old group （n=476） ,65-69 years old group （n=370） ,70-74 years old group （n=238）and ≥75 years old group （n=226） .Factors influencing their bilateral carotid IMT were analyzed by multivariate linear regression analysis .Results The bilateral carotid IMT increased with age .The left carotid IMT was significantly thicker than the right carotid IMT in all groups except in 65 -69 years old group . Multivariate linear regression analysis showed that the influence of age ,smoking index ,blood pressure ,instant blood glucose and total cholesterol was more significant on the left carotid IMT than on the right carotid IMT .The influence of gender was more significant on the right carotid IMT than on the left carotid IMT .Conclusion The left carotid IMT is thicker than the right carotid IMT in subjects with their age〉55 years .The influence of age ,gender ,smoking index ,blood pressure ,instant blood glucose and total cholesterol is different on their bilateral carotid IMT .