期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

脂联素及其受体的研究现状 被引量：3

下载PDF
导出
摘要 脂联素（adiponectin）是脂肪细胞分泌、唯一随脂肪含量的增加而表达下降的细胞因子,它与受体在能量分配、贮存和消耗以及疾病方面起着不可忽视的作用[1,2].脂联素通过结合脂联素受体（adiponectin receptors）可以提高糖、脂的代谢,使动物向不利于脂肪形成的方向发展.同时,不同组织脂联素受体的分布不同,脂联素受体的种类与脂联素的结合力和敏感性密切相关,而且脂联素可能是通过不同的受体发挥其在相应组织的功能[3].本文就脂联素及其受体的结构特征、脂联素及其受体表达调控以及对脂肪代谢的作用做一阐述.
作者 孙永刚
机构地区 青海省畜牧兽医科学院
出处 《青海畜牧兽医杂志》 2014年第3期45-46,共2页 Chinese Qinghai Journal of Animal and Veterinary Sciences
基金 科技部国际科技合作项目(2013DFA31420) 科技部国际科技合作项目(2008DFA31100)
关键词 脂联素 受体 脂肪含量 脂肪代谢 细胞分泌 细胞因子 能量分配 脂肪形成
分类号 R392.6 [医药卫生—免疫学]
  • 相关文献

参考文献24

  • 1Fu Y, Luo N and Kleinr L. Adiponeetin promotes adipoeyte differentiation,insulin sensitivity, and lipid accumulation [J]. Journal of Lipid Research,2005,46(7): 1369-1379.
  • 2Yamauehi T, Tsuehida A, Ito Y, et al. Expression levels of adiponeetin receptors and adiponeefin sensitivities in routine models of altered adiposity and insulin sensitivity [J]. Diabetes, 2004, 53: A354-355.
  • 3徐国庆,龚道清,储冬生,董飚,孟和.鹅脂联素基因的克隆、序列分析及组织表达[J].农业生物技术学报,2008,16(6):941-946. 被引量：10
  • 4Scherer PE, Williams S,Fogliano M,et al. A novel serum protein similar to Clq,produeed exclusively in adipocytes [J]. J Biol Chem, 1995, 270(45) : 26746-26749.
  • 5Hu E,Liang P,Spiegelman BM. AdipoQ is a novel adipose - specific gene dysregulated in obesity [J]. J Biol Chem, 1996, 271 ( 18 ) : 10697-10703.
  • 6Maeda K, Okubo K, Shimomura I, et al. cDNA cloning and expression of a novel adipose specific collagen - like factor, apM1 (AdiPose" Most abundant Gene transcript 1 ) [J ]. Biochem Biophys Res Commun, 1996, 221 (2) : 286-289.
  • 7Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose - specific protein, adiponectin, in obesity [J]. Biochem Biophys Res Commun,1999, 257( 1 ) : 79-83.
  • 8Fruebis J, Tsao TS, Javorschi S, et al. Proteolytic cleavage product of 30 - kDa adipocyte complement - related protein increases fatty acid oxidation in muscle and causes weight loss in mice[J]. Proc Nail Acad Sci USA,2001,98(4) : 2005-2010.
  • 9Yamauehi T, Kamon J, Ito Y, et al.Cloning of adiponectin receptors that mediate antidiabetic metabolic effects [ J]. Nature, 2003, 423: 762-769.
  • 10Trujillo ME, Scherer PE. Adiponectin: journey from an adipocyte secretory protein to biomarker of the metabolic syndrome [J] J Intern Med,2005,257: 167-175.

二级参考文献40

  • 1敖金霞,李辉,王启贵,王宇祥,唐志权.鹅生长激素基因的克隆和组织表达[J].农业生物技术学报,2004,12(5):552-555. 被引量：21
  • 2叶承志,张龙江,王宏伟,林汉华.油酸诱导SW872前脂肪细胞分化过程中脂联素受体的表达[J].实用儿科临床杂志,2005,20(9):891-893. 被引量：5
  • 3Berryman D E, List E O, Coschigano K T, Behar K, Kim J K and Kopchick J J . Comparing adiposity profiles in three mouse models with altered GH signaling [J]. Growth Horm & IGF Research, 2004, 14:309-318.
  • 4Chabrolle C, Tosca L, Crochet S, Tesseraud S and Dupont J. Expression ofadiponectin and its receptors (AdipoR1 and AdipoR2) in chicken ovary: Potential role in ovarian steroidogenesis [J]. Domestic Animal Endocrinology, 2007, 33:480-487.
  • 5Devaraj S, Siegel D and Jialal I. Simvastatin (40 mg/day), adiponectin levels, and insulin sensitivity in subjects with the metabolic syndrome [J]. American Journal of Cardiology, 2007, 100:1397-1399.
  • 6Ding S T, Liu B H and Ko Y H. Cloning and expression of porcine adiponectin and adiponectin receptor 1 and 2 genes in pigs [J]. Journal of Animal Science, 2004, 82 (11): 3162-3174.
  • 7Dong B(董飚).Cloning, expression and function of duck adiponectin and its receptor genes (D).Yangzhou University. 2007 a.
  • 8Han S H, Quon M J, Kim J and Koh K K. Adiponectin and cardiovascular disease: Response to therapeutic interventions [J]. Journal of American College Cardiology, 2007, 49(5):531-538.
  • 9Higurashi S, Kunieda Y, Matsuyama H and Kawakami H. Effect of cheese consumption on the accumulation of abdominal adipose and decrease in serum adiponectin levels in rats fed a calorie dense diet [J]. International Dairy Journal, 2007, 17: 1224-1231.
  • 10Hirabayashi M, Ijiri D, Kamei Y, Tajima A and Kanai Y. Transformation of skeletal muscle from fast- to slow twitch during acquisition of cold tolerance in the chick [J]. Endocrinology, 2005, 146(1):399-405.

共引文献21

同被引文献55

  • 1张辉,丛立新,张才,王哲.NEFA和BHBA对体外培养的脂肪细胞HSL、ADPN mRNA表达的影响[J].中国兽医学报,2008,28(7):840-843. 被引量：3
  • 2崔丽娟,都健.脂联素与炎症及胰岛素抵抗关系的研究进展[J].国际内分泌代谢杂志,2006,26(B04):44-46. 被引量：16
  • 3董飚,孟和,顾志良,龚道清.脂联素与脂联素受体的研究进展[J].中国畜牧兽医,2007,34(2):44-48. 被引量：7
  • 4魏文青.脂联素的研究现状与展望[J].标记免疫分析与临床,2007,14(2):122-125. 被引量：24
  • 5Ramachandran R, Maddineni S, Oc6n-Grove O, et al. Expression of adiponectin and its receptors in avian species [J]. General and Comparative Endocrinolo- gy, 2013,190 : 88-95.
  • 6Yamauchi T, Kamon J, Waki H, et al. Globular adi- ponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis [J]. Biol Chem, 2003,278 (4) : 2461-2468.
  • 7Yamauchi T, Iwabu M, Okada-Iwabu M, et al. Adi- ponectin receptors:A review of their structure, func- tion and how they work[J]. Best Pract Res Clin En- docrinol Metab, 2014,28 ( 1 ) : 15-23.
  • 8Breitfeld J, Stumvoll M, Kovacs P. Genetics of adi- ponectin[J]. Biochimie,2012,94(lO) :2157-2163.
  • 9Li M, Liu F. Up- and down-regulation of adiponectin expression and multimerization: Mechanisms and therapeutic implication[J]. Biochimie, 2012,94 ( 10 ) : 2126-2130.
  • 10Ling F, Li J, Chen Y, et al. Cloning and characteriza- tion of the 5Cflanking region of the pig adiponectin gene[J]. Biochemical and Biophysical Research Com- munication, 2009,381 (2) ; 236-240.

引证文献3

二级引证文献13

青海畜牧兽医杂志
2014年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部