摘要
目的比较瑞舒伐他汀和辛伐他汀对慢性心力衰竭(CHF)的疗效。方法选取CHF患者108例,随机分为两组,在常规治疗的基础上,分别加用辛伐他汀(20 mg/d)和瑞舒伐他汀(20 mg/d)治疗,疗程为6个月。在治疗前后,检测患者低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、高敏C反应蛋白(hs-CRP)、B型尿钠肽(BNP)、左室射血分数(LVEF)、左室舒张末内径(LVEDD),并评估纽约心脏病学会(NYHA)心功能分级,记录6 min步行距离。结果瑞舒伐他汀组和辛伐他汀组总有效率分别为90.74%、75.93%,有统计学差异(P<0.05)。治疗后,两组LVEF、LVEDD、LDL-C、hs-CRP、BNP和6 min步行距离均较治疗前有所改善(P<0.05),且瑞舒伐他汀组较辛伐他汀组改善程度更明显(P<0.05)。结论瑞舒伐他汀联合常规治疗对CHF疗效优于辛伐他汀联合常规治疗,值得推广。
Objective To compare the curative effects of rosuvastatin and simvastatin on chronic heart failure（ CHF ）. Methods 108 patients of CHF were randomly divided into 2 groups：rosuvastatin group and simvastatin group. The routine treatment was applied to both groups,while simvastatin,20 mg/d,was added to patients in simvastatin group and rosuvastatin,20 mg/d,to patients in rosuvastatin group;the total course lasted for 6 months. Before and after treatment,detections of LDL-C,HDL-C,hs-CRP,BNP,LVEF and LVEDD were performed as well as the evaluation of cardiac function according to New York Heart Association（ NYHA ） classification and the distance of 6-minute walk test（6MWT）. Results The total effective rate was 90. 74% in rosuvastatin group and 75.93% in simvastatin group,the difference was of statistical significance（P ﹤0. 05）;improvement in LVEF,LVEDD,LDL-C,hs-CRP,BNP and 6MWT was found in both groups after treatment（P﹤0. 05）and the improvement in rosuvastatin group was greater than that in simvastatin group（P﹤0. 05）. Conclusions The effect of rosuvastatin combined with routine treatment is much superior to that of simvastatin on CHF,and a wider clinical application should be promoted.
出处
《西南国防医药》
CAS
2014年第6期601-604,共4页
Medical Journal of National Defending Forces in Southwest China
