不孕妇女生殖道感染病原体检测分析

Analysis of the pathogens of reproductive tract infection in infertile women

目的分析不孕妇女生殖道感染的病原体分布和支原体药敏。方法对260例不孕妇女(试验组)的阴道分泌物和宫颈分泌物进行相关病原体的实验室检查,并与260例妊娠妇女(对照组)进行比较。结果试验组妇女生殖道感染的病原体阳性率为61.2%。病原体检出前3位依次为支原体(47.7%)、假丝酵母菌(30.0%)和细菌性阴道病(BV)病原菌(16.7%);BV病原菌、支原体和pH值在不孕妇女与对照组间差异具有统计学意义(P<0.05),其他病原体和生殖道清洁度在试验组与对照组间差异无统计学意义(P>0.05)。多西环素和米诺环素对解脲支原体的敏感率高达90%以上,喹诺酮类药物对解脲支原体的敏感率低于40%。结论 BV病原菌和支原体感染是引起妇女不孕的重要因素,须加强监测,合理使用抗菌药物。

Objective To analyze the distribution of reproductive tract infection（RTI）pathogens and the drug sensitivity of My-coplasma in infertile women.Methods Experimental examinations of the pathogens related to RTI were performed in 260 cases of infertile women（test group）and compared with 260 cases of pregnant women（control group）.Results In test group,the positive rate of RTI pathogens was 61.2%.The top 3 pathogens were Mycoplasma （47.7%）,Candida （30.0%）and bacterial vaginosis （BV）pathogens（16.7%）.There were significant differences of BV pathogens,Mycoplasma,and pH value between test group and control group（P 〈0.05）.And the differences of other pathogens and the cleanliness were not significant between test group and control group（P 〉0.05）.The drug sensitivity rates of Ureaplasma urealyticum to doxycycline and minocin were above 90%,and which to quinolone was less than 40%.Conclusion BV pathogens and Mycoplasma infection is one of the important factors which could affect women infertility.It is necessary to strengthen the monitoring and rational use of antimicrobial agents.