鹰潭地区女性宫颈HPV感染率及其基因分型特点

The rate of HPV infection and HPV genotyping in women from Yingtan

目的：探讨鹰潭地区女性宫颈人乳头瘤病毒（HPV）感染率及其病毒基因分型特点，为该地区宫颈癌防治提供更科学、可靠的临床数据。方法回顾分析2011年1月至2013年6月来鹰潭市人民医院铁路分院门诊妇科就诊及体检的妇女4165例，采用核酸扩增和反向点杂交技术对23种 HPV 基因型进行检测，然后对检测结果进行分析。结果在4165例患者中，HPV阳性者有1311例，感染率为31．48％；一重感染率为20．86％，二重感染率为6．27％，三重感染率为2．76％，四重感染率为0．84％，四重以上感染率为0．72％。感染率最高的基因型别是 HPV 52型，占12．43％，其次为 HPV 43、58、16型。＞20～25岁者感染率最高，为43．19％。结论鹰潭地区女性宫颈 HPV 感染率有较高的区域性，以 HPV 52、43、58、16等亚型感染居多。

Objective To determine the rate of human papillomavirus virus （HPV）infection and HPV subtypes distribution in women from Yingtan,so as to provide more reliable and scientific clinical data for the prevention and control of cervical carcinoma. Methods 4 165 women were retrospectively analyzed,who were outpatients or physical examination people of Railroad Branch of People′s Hospital of Yingtan from January 2011 to June 2013.23 types of HPV genotypes were detected in cervical samples by using the nucleic acid amplification and reverse dot hybridization technology.Results 1 311 HPV positive samples were found in 4 165 women （31.48%）,of which 20.86% with single HPV genotype infection,6.27% with double HPV genotypes infection, 2.76% with triple HPV genotypes infection,0.84% with quadriad HPV genotypes infection,and 0.72% with more than quadriad HPV genotypes infection.HPV52 had the highest infection rate,accounting for 12.43%,following with HPV43,58,16.〉20-25 age group had the highest infection rate（43.19%）.Conclusion Women have high HPV infection rate in Yingtan,and HPV subtypes such as HPV52,43,58,16 are superior infection genotypes.