冠心病PCI术后再狭窄患者IL-18、IL-10和基质金属蛋白酶-9水平的研究

Study of interleukin-18,interleukin-10 and matrix metalloproteinase-9 levels in restenosis after percutaneous coronary intervention

目的观察冠心病经皮冠状动脉介入治疗(PCI)术后再狭窄患者血清白细胞介素(IL)-18、IL-10和基质金属蛋白酶-9(MMP-9)水平,探讨炎性因子在冠心病PCI术后再狭窄中的作用。方法冠心病PCI术后患者,根据再次冠脉造影是否存在支架内再狭窄分为支架内再狭窄(ISR)组(n=68)和非再狭窄(非ISR)组(n=173),109例疑似但经冠脉造影排除冠心病的人群作为对照组。测定各组血清IL-18、IL-10和MMP-9浓度。结果 ISR组和非ISR组血清IL-18和MMP-9浓度明显高于对照组,而血清IL-10浓度则明显低于对照组;与非ISR组相比,ISR组血清IL-18和MMP-9水平明显增高,而IL-10浓度则明显降低,差异均有统计学意义(P<0.05)。结论 IL-18、IL-10和MMP-9与再狭窄有关,炎性反应可能是冠心病PCI术后再狭窄的重要影响因素之一。

Objective To investigate the levels of IL-18,IL-10 and MMP-9 in coronary heart disease（CAD）patients with instent restenosis（ISR）after percutaneous coronary intervention （PCI）treatment,so as to discuss the influence of inflammatory factors to ISR after PCI.Methods CAD patients with ISR after PCI were angiographically reevaluated and formed the ISR group（n=68）and the non-ISR group（n=173）based on the presence or absence of ISR.109 subjects without angiographic evidence of CAD formed a reference control group（control group）.The plasma IL-18,IL-10 and MMP-9 concentrations of subjects were measured. Results The concentrations of serum IL-18 and MMP-9 in ISR group and non-ISR group were significantly higher than control group,while IL-10 level was the opposite.Contrasted with non-ISR group,the concentrations of serum IL-18 and MMP-9 in ISR group were significantly higher,but IL-10 level was the opposite too.There were significantly statistical differences（P 〈0.05）Con-clusion There is significant correlation between ISR and serum levels of IL-18,IL-10 and MMP-9.The inflammation may have important impact on the process of ISR.