静脉导管病原菌感染及耐药性分析

Analysis of the infection and drug resistance of pathogenic bacteric in venous catheter

目的探讨该院静脉导管相关性感染的病原菌分布及耐药状况,为临床合理使用抗菌药物提供依据。方法回顾性分析2009年1月至2012年12月该院送检的369份静脉导管标本的细菌培养和药敏结果。结果 369份静脉导管标本中,共分离病原菌161株,阳性率为43.6%,革兰阳性菌83株,占51.6%,其中表皮葡萄球菌分离最高;革兰阴性杆菌63株,占39.1%,其中以肺炎克雷伯菌和鲍曼不动杆菌为主;真菌15株,占9.3%,以近平滑念珠菌分离最多。未检出耐万古霉素和耐利奈唑胺的革兰阳性球菌,碳青霉烯类抗菌药物对革兰阴性杆菌有较好的抗菌活性。结论该院表皮葡萄球菌和肺炎克雷伯菌是静脉导管感染的主要病原菌,应引起重视。

Objective To investigate the hospital distribution and drug resistance of pathogens of venous catheter-related infection,so as to provide basis for appropriate usage of antibiotics in clinic.Methods The culture and drug susceptibility results of 369 venous catheter were analyzed retrospectively from 2009 January to 2012 December.Results 161 strains of pathogens were detected among 369 venous catheter,the positive rate was 43.6%.There were 83 strains of Gram positive bacteria,accounting for 51.6%,and Staphylococcus epidermidis had the highest positive rate.There were 63 strains of Gram negative bacteria,accounting for 39.1%,and Klebsiella pneumoniae and Bauman Acinetobacter were main isolated bacteria.There were 15 strains of Fungi,accounting for 9.3%,and Candida parapsilosis had the highest positive rate.There was none Gram positive bacteria resistant to vancomycin and linezolid.Carbapenems remained high activity against Gram negative bacteria.Conclusion Staphylococcus epidermidis and Klebsiella pneumoniae are mainly detected in venous catheter in the hospital infection.