催乳素水平对多囊卵巢综合征患者卵泡生长的影响

Relation between prolactin and ovulation disorder in polycystic ovary syndrome

目的探讨血清催乳素水平对于诱发排卵的多囊卵巢综合征（PCOS）患者卵泡生长的影响。方法应用促排卵药物（克罗米芬＋人绒毛膜促性腺激素）诱发PCOS患者（89例）卵泡生长，根据卵泡生长情况分为卵泡生长正常组（49例）及卵泡生长障碍组（40例）。在诱发排卵的月经周期中，应用电化学发光法测定患者不同时期的卵泡大小及血清催乳素。结果诱发卵泡生长的第0、5、10天，2组卵泡生长大小、催乳素差异均无统计学意义（均P＞0.05），诱发卵泡生长第15天，卵泡生长正常组卵泡大小大于卵泡生长障碍组[（19.38±0.19）mm比（15.43±0.11） mm，t=-1.823，P＜0.05]；生长正常组血清催乳素水平低于卵泡生长障碍组[（20.43±0.10）μg/L比（26.38±0.19）μg/L，t=-1.923，P＜0.05]。卵泡生长障碍组患者血清催乳素激素水平与体质量﹑三酰甘油﹑血糖呈正相关（r=0.806，P＜0.05；r=0.361，P＜0.05；r=0.336，P＜0.05）；卵泡生长正常组血清催乳素水平与体质量﹑三酰甘油﹑血糖呈正相关（r=0.169，P＜0.05；r=0.273，P＜0.05；r=0.184，P＜0.05）。结论卵泡生长障碍组患者血清催乳素水平较高，催乳素水平过高在一定程度上影响正常卵泡生长。

ObjectiveTo analyze the relation between plasma level of prolactin and ovulation disorder in polycystic ovary syndrome （PCOS）. MethodsTotally 89 cases with PCOS were induced with ovulation by clomiphene and human chorionic gonadotropin during menstrual cycle of induced ovulation. The patients were divided into two groups according to ovulation [follicle growth normal group （49 cases） and follicle growth disorder group （40 cases）].The levels of prolactin were determined by electrochemical luminescence method at different follicular development period and ovulatory time. Results The levels of prolactin of two groups were different with 5 mm,10 mm,15 mm sizes during the follicular phase（all P 〉0.05）.The different of size the follicular in follicle growth normal group was significantly larger than that in follicle growth disorder group [（19.38±0.19）mm vs （15.43±0.11）mm,t=1.823,P〈0.05]. The difference of the level of prolactin in follicle growth normal group was significantly lower than that in follicle growth disorder group [（20.43±0.10） μg/L vs （26.38±0.19）μg/L,t=-1.923,P〈0.05]. At no ovulatory term, prolactin was related to body weight,blood glucose,triglycerides （r=0.806,P〈0.05;r=0.361,P〈0.05;r= 0.336,P〈0.05）.The level of prolactin of ovulatory term was related to body weight,blood glucose and triglycerides（r=0.169,P〈0.05;r=0.273,P〈0.05; r=0.184,P〈0.05）. ConclusionsPatients with no ovulatory term have higher plasma levels of prolactin. High levels of prolactin may play an important role in the development of ovulatory.