抗磷脂综合征的皮肤表现

Cutaneous manifestations of antiphospholipid syndrome

抗磷脂综合征是一种以反复动静脉形成、流产、血小板减少及血抗磷脂抗体持续阳性为特征的系统性自身免疫性疾病。该综合征可以累及包括皮肤在内的全身任何器官。临床上皮肤表现可作为其首要症状,多见于网状青斑、Sneddon综合征、白色萎缩、皮肤溃疡坏死、斑状萎缩和Degos病等。掌握抗磷脂综合征的皮肤表现对其早期诊断、及时治疗极为关键。

Antiphospholipid syndrome （APS） is a systemic auto-immune disorder characterised by recurrent arterial and/or venous thrombosis, pregnancy losses, thrombocytopenia and the presence of elevated and persistent levels of antiphospholipid antibodies. It may potentially affect any organ including the skin. Dermatologic manifestations may be the ifrst indication of APS and may be noticeable as livedo reticularis, Sneddon＆#39;s syndrome, atrophie blanche, skin ulcerations and necrosis, anetoderma, or Degos＆#39; disease. Knowledge of the cutaneous manifestations of APS is critical in the early identiifcation and fast treatment of APS patients.