摘要
以N-羟基琥珀酰亚胺(NHS)和1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐(EDC·HCl)为催化剂,将制备的双羧基聚乙二醇(COOH-PEGCOOH)和部分巯基化聚乙烯亚胺(PEI-SHx)先后接枝于壳聚糖分子,得到巯基化壳聚糖衍生物(CS-PEGPEI)。利用傅立叶红外光谱仪(FT-IR)和核磁共振仪(1 H NMR)对其结构进行表征;通过透析法制备自聚集纳米粒,透射电子显微镜(TEM)和动态激光粒度分析仪(DLLS)分析测试自聚集纳米粒显示,自聚集纳米粒为球状纳米胶束,该纳米球有望成为纳米药物及基因的载体。
Thiolated chitosan derivative （CS-PEG-PEI） was synthesized by grafting double carboxy-terminated PEG and partly thiolated polyethylenimine （PEI-SHx） onto chitosan with NHS/EDC as catalyst. The chemical structure of polymer was characterized by the Fourier transform infrared spectroscopy（FT-IR） and proton nu- clear magnetic resonance（1 H NMR）, the self-assembled nanoparticles was prepared by probe sonication-dialysis method. The measurements of transmission electron microscope（TEM） and dynamic light scattering（DLS） in- dicated that the self-aggregates were nanoparticles. This novel nanoparticle system was promising to be a good drug carrier and gene carrier.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2014年第6期140-143,共4页
Journal of Functional Materials
基金
国家自然科学基金资助项目(31271023,91323104)
中央级公益性科研院所基本科研业务费专项资金资助项目(院所1304)
关键词
壳聚糖
聚乙二醇
巯基化聚乙烯亚胺
自组装
chitosan
polyethylene glycol
thiolated polyethylenimine
self-assembled
