获得性免疫综合征患者抗结核治疗中保肝药的预防性应用分析

Prophylactic Application of Hepatic Protectants in Anti-TB Treatment of AIDS Patients

目的观察获得性免疫综合征(艾滋病)患者在抗结核治疗过程中保肝药对药物性肝损害的预防作用。方法对比分析我院2008年11月-2013年6月初始抗结核治疗的艾滋病患者,在加用和未加用保肝药的条件下,强化期肝功能损伤的情况。结果加用保肝药的患者肝功能损伤的发生率为26.9%,未加用保肝药的患者肝功能损伤的发生率为37.9%。结论对艾滋病合并结核的患者,初始治疗即加用保肝药可以减少肝功能损伤的发生。

OBJECTIVE To observe the prophylactic effect of hepatic protectants in the anti-TB treatment of acquired im- mund deficiency syndrome patients. METHODS Cases from 2008 through 2013 with or without hepatic protectants were analysed to compare the changes in transaminase. RESULTS Patients with hepatic proteetants showed a 26.9% of rate of hepatic injury, while those without hepatic protectants showed a 37.9% of rate of hepatic injury. CONCLUSION Prophy- lactic application of hepatic protectants can decrease the occurrence of hepatic injury during the anti-TB treatment of AIDS pa- tients.