摘要
目的探讨细丝蛋白A(FLNa)和热休克蛋白90(HSP90)在乳腺癌组织小的表达及其与乳腺癌临床生物学行为的关系。方法应用免疫组织化学法检测69例乳腺癌组织和癌旁组织中FLNa和HSP90的表达水平。结果FLNa在乳腺癌组织中表达率为68.12%,在癌旁组织中表达率为10.14%,两者差异有统计学意义(P〈0.01),FLNa表达水平与乳腺癌组织学分级、TNM分期、淋巴结转移明砂相关(P〈0.05);HSP90在乳腺癌组织中表达率为44.93%,在癌旁组织中表达率为8.70%,两者蒡异有统计学意义(P〈0.01),HSP90表达水平与乳腺癌肿瘤大小、组织学分化程度、TNM分期、淋巴结转移等明显相关(P〈0.05)。结论同时检测FLNa和HSP90有助于评估乳腺癌的恶性程度、判断其转移潜能。
Objective To explore the expression of filam in A (FLNa) and heat shock protein 90 (HsPgo) and the clinical biological behavior of breast carcinoma. Methods FLNa and HSP90 expression in 69 cases of human breast carcinoma tissues and non-cancerous adjacent breast tissues(5 cm distance away from the margin of breast carcinoma) were examined by using immunohistochemical method. Results The expression rate of FLNa was 68. 12% in breast carcinoma tissues, and 10. 14% in non-cancerous adja- cent breast tissues ( P 〈 0. 01 ), the expressions of FLNa were related breast carcinoma to histology grade, TNM stage and lymph node metastasis ( P 〈 0. 05 ) ; the expression rate of HSP90 was 44. 93% in breast carcinoma tissues, and 8.70% in non-cancerous adjacent breast tissues (P 〈 0. 01 ). there was a close relation between the expression of HSP90 and tumor size, histology grade, TNM stage and lymph node metastasis (P 〈 0. 05). Conclusion Detecting the expressive levels of FLNa and HSP90 simultaneously might be helpful for evaluating the malignance and predicting the metastatic potential of breast carcinoma.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2014年第6期1312-1313,共2页
Chinese Journal of Experimental Surgery