维U颠茄铝胶囊Ⅲ含量测定方法的改进

Improvement of Determination Method of Vitamin U Belladonna and Aluminium Capsules Ⅲ

目的：改进维U颠茄铝胶囊Ⅲ中维生素U和氢氧化铝含量测定方法。方法：从供试液处理方法（由过滤改为离心后取上清液）改进维生素U含量测定方法；从样品分离提纯操作和滴定时减少指示液的用量方面改进氢氧化铝含量测定方法；同时比较改进法与原标准方法测定样品含量的结果。结果：改进法的方法考察学结果符合要求；两种方法测得维生素U及氢氧化铝的含量结果基本一致，但改进方法测定耗时减少（维生素U由约6～10h缩短为约1h，氢氧化铝由约4～5h缩短为约2～3h）。结论：改进法省时、操作简便，滴定终点容易判断，含量测定结果准确，精密度好，可作为维U颠茄铝胶囊Ⅲ含量测定的替代方法。

OBJECTIVE： To improve the determination method of Vitamin U belladonna and aluminium capsules Ⅲ. METH- ODS ： Determination method of vitamin U was improved in terms of the sample .processing methods, that is, the supernatant after centrifugation replaced the original filtering. Determination method of aluminum hydroxide was improved by reducing the amount of indicator solution during separation and purification and titration. Content determination of samples by improved method was compared with that by original standard method. RESULTS： Improved method was in line with the requirements of methodology. Results of content determination of vitamin U and aluminum hydroxide by two methods were basically same to each other; however, improved method took shorter to determine the contents （for vitamin U： 1 h instead of 6-10 h; for aluminum hydroxide： 2-3 h instead of 4-5 h）. CONCLUSIONS： Improved method saves time, and is simple and easy to determine the end point of titration, with accurate and precise results. It can be used as an alternative method for Vitamin U belladonna and aluminium capsules Ⅲ.