中药药氧疗法治疗脑卒中后失眠症的临床疗效评价分析

Clinical Evaluation of Efficacy of Traditional Chinese Medicine-Oxygen Therapy for Insomnia after Stroke

目的:观察中药药氧疗法治疗脑卒中后失眠症的临床疗效及不良反应。方法:将66名脑卒中后失眠症患者随机分成2组,对照组给予艾司唑仑片(由湖南洞庭药业有限公司生产,1 mg/片)口服治疗,每天睡前口服1 mg;观察组给予药氧吸入治疗,每天睡前1次,20 min/次。采用匹兹堡睡眠质量指数(PSQI)、按照尼莫地平法计算评分减少率来评定疗效。2组疗程均为4 w,并分别在治疗前、治疗后1 w、治疗后2 w、治疗后4 w及停止治疗1 w时进行PSQI评分。结果:对照组脱落3例,治愈11例,显效11例,有效5例,未愈3例;观察组脱落1例,治愈12例,显效10例,有效6未愈4例。2组疗效无显著差异。观察组PSQI评分在治疗后1 w及停止治疗后1 w时低于对照组,比较有显著差异,另2组不良反应发生率比较有显著性差异。结论:中药药氧疗法可加快睡眠质量改善的速度,不良反应少,并且可以减缓脑卒中患者失眠症状的反弹。

Objective： To observe the clinical efficacy and adverse reactions of traditional Chinese medicine-oxygen therapy for insomnia after stroke. Methods： 66 patients with insomnia after stroke were randomly divided into treatment group （n = 33 ） and con- trol group （ n = 33 ）, the control group was treated with Estazolam （ Produced by Hunan Dongting Pharmaceutical Co. , Ltd. 1 mg/ piece）, 1 mg daily at bedtime; the treatment group was treated with the Traditional Chinese medicine-oxygen therapy （TCMOT） once a day at bedtime, 20 minutes every time. We evaluated the efficacy by using the Pittsburgh Sleep Quality Index （PSQI） and the re- duction rate of nimodipine method. The two groups＇ treatment lasted four weeks, and we recorded the PQSI score respectively before treatment, after treatment, a week after treatment, two weeks after treatment, and four weeks after treatment, and one week after the treatment stopped. Results ： In the control group, 3 cases quit, 11 cases cured, 11 cases got significant effect while 5 cases effective, and 3 cases unhealed. In the treatment group, 1 case quit, 12 cases cured, 10 cases got significant effect while 6 cases effective, and 4 cases unhealed. There was no significant difference between two groups in the whole efficacy. But the PQSI score showed significant difference between the two groups when in one week after treatment and one week after the treatment stopped. And there was a signifi- cant difference between the two groups＇ incidence of adverse reactions. Conclusion： The traditional chinese medicine-oxygen therapy can accelerate the speed of improvement of sleep quality, it has fewer adverse reactions, and can slow the rebound of symptoms of in-somnia after stroke.