超声辐射下取代苯乙腈与芳香醛的knoevenagel缩合反应

On Ultrasound Promote Knoevenagel Condensation of Benzyl Cyanides with Aromatic Aldehydes

在超声辐射下,以KOH为催化剂,由取代苯乙腈与芳香醛进行诺文葛尔缩合反应,最终高产率地得到缩合产物,产物结构经红外光谱、核磁共振、质谱等确证.该反应时间短,操作简便,收率较高,为该类化合物的合成提供了一种有效的新方法.

The condensations of benzyl cyanides with aromatic aldehydes under ultrasound irradiation have been studied in this paper.All the reactions occur with excellent yields and short time in the presence of potassium hydroxide as catalyst.The structure of product has been confirmed by IR,NMR,mass spec-trometry etc.The reaction could be worked up easily with short reaction time,high yields and environ-mental friendliness,which provides an effective new method for the synthesis of these compounds.