摘要
目的探讨血清25羟维生素D3[25-(OH)D3]水平与2型糖尿病视网膜病变(diabetic retinopathy,DR)的关系。方法选取144例2型糖尿病患者,分为无DR组(NDR组)50例、非增生期DR组(NPDR组)48例和增生期DR组(PDR组)46例,并选取同期来本院体检的46例健康者为对照组(NDM组)。对每位患者进行临床资料收集及常规生化指标检测,采用电化学发光法检测所有受试者血清25-(OH)D3水平。结果 NDR组患者血清25-(OH)D3浓度为(28.10±10.23)ng·mL-1,明显低于NDM组的(31.59±9.12)ng·mL-1,NPDR组患者血清25-(OH)D3浓度为(25.18±10.56)ng·mL-1,明显低于NDR组,而PDR组患者血清25-(OH)D3浓度为(22.29±10.82)ng·mL-1,又明显低于NPDR组,差异均有统计学意义(均为P<0.05)。Pearson相关分析显示,血清25-(OH)D3水平与病程、HbA1C、血肌酐均呈统计学上的负相关(r=-0.16、-0.19、-0.22,均为P<0.05)。结论 2型DR患者血清25-(OH)D3水平明显降低,且与DR的严重程度存在关联。
Objective To investigate the relationship between serum 25- Hydroxyvitamin D3 [ 25 - （OH） D3 ] concentrations and diabetic retinopathy （DR） in type 2 diabetic patients. Methods A total of 144 patients with type 2 diabetes mellitus and 46 non-diabetic healthy controls were enrolled in this study. All the diabetic patients were divided into three groups ：non-diabetic retinopathy group （NDR group ,50 cases）, non-proliferative diabetic retinopathy（ NDPR group, 48 cases） ,and proliferative diabetic retinopathy（ PDR group,46 cases）. The 25-（OH） D3 levels in serum were measured by electrochemiluminescence immunoassay. Results NDR group had lower 25- （OH） D3 levels than NDM group [ （28. 10 ±10.23）ng · mL^-1 vs（31.59 ±9.12）ng · mL^-1] （P 〈 0. 05 ）. NPDR group had lower 25- （OH） D3 levels than NDR group [ （25.18 ± 10.56 ） ng · mL^-1 vs（28.10 ±10.23）ng · mL^-1] （P 〈0.05） ,and PDR group had lower 25-（OH） D3 levels than NPDR group[ （22.29 ± 10.82）ng · mL^-1 vs（25.18 ±10.56）ng · mL^-1] （P 〈 0.05 ）. The result of pearson＇ s correlation analysis showed that serum 25-（OH） D3 con- centration was negative correlated with course of illness （ r = - 0.15, P 〈 0.05 ）, HbA1 C （r= -0.19,P〈0.01）and creatinine（r = -0.22,P〈0.01）. Conclusion Serum level of 25- （OH） D3 in type 2 diabetes mellitus patients with DR is obviously lower, and severity of DR is associated with serum 25-（OH） D3 concentration.
出处
《眼科新进展》
CAS
北大核心
2014年第6期583-585,共3页
Recent Advances in Ophthalmology
