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miR-183/96/182在眼科学的研究进展 被引量：3

Research progress on miR-183/96/182in ophthalmology
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摘要 miR-183/96/182簇(miR-183/96/182 cluter,miR-183C)是一组在视网膜中高度表达的感觉器官特异性microRNA。近年来发现miR-183C在视网膜发育、分化和光感受器功能活动中发挥作用,并与眼部炎症、肿瘤、视网膜色素变性等疾病存在密切的联系。本文将对miR-183C在眼科学的研究进展,包括其在眼部组织的分布特点,以及对眼部组织的发育、生理和某些眼部疾病的基因调控等进行综述。 MiR-183/96/182（miR-183C） is a group of sensory organ-specific microR- NA ,which is highly expressed in the retina. Recent studies have indicated that miR-183C plays roles in retinal development, differentiation, and functions of photoreceptor. In addition,miR-183C is closely related in ocular inflammation,tumors and retinitis pigmentosa. This article reviews the major research advances about miR-183C in ophthalmology,including its expression characteristics in eye tissues, and gene regulation of miR- 183 C in the ocular development, physiology and pathology.
作者 何宇 范玮 张军军
机构地区 四川大学华西医院西藏成办分院眼科 四川大学华西眼科中心
出处 《眼科新进展》 CAS 北大核心 2014年第6期589-593,共5页 Recent Advances in Ophthalmology
关键词 MICRORNA 视网膜 光感受器 靶基因 microRNA retina photoreceptors target gene
分类号 R77 [医药卫生—眼科]
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参考文献44

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共引文献14

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二级引证文献8

眼科新进展
2014年 第6期

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