枳壳健胃颗粒对胃粘膜损伤大鼠的保护作用

The protective effects of Zhiqiao Jianwei Granules on gastric lesion in rats

目的:探讨枳壳健胃颗粒对大鼠胃粘膜损伤的保护作用。方法:大鼠随机分为正常组、模型组、枳壳健胃颗粒低剂量组(2.7 g/kg)、枳壳健胃颗粒中剂量组(5.4 g/kg)、枳壳健胃颗粒高剂量组(10.8 g/kg)和雷尼替丁组(0.027 g/kg)。给予相对应剂量的药物,正常组与模型组给予等量的生理盐水,每天1次,连续15d。末次灌胃给药后1h,除正常组外,其余各组用75%乙醇诱发大鼠胃粘膜损伤模型。检测各组大鼠血清中超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)和前列腺素E2(PGE2)含量,计算大鼠胃粘膜溃疡指数,并对病变组织进行病理学观察。结果:病理学切片显示枳壳健胃颗粒能明显改善大鼠胃粘膜充血、水肿及炎性浸润程度,枳壳健胃颗粒(5.4 g/kg)剂量组、枳壳健胃颗粒(10.8 g/kg)剂量组能明显降低模型组大鼠溃疡指数和血清中MDA的含量,提高大鼠血清中SOD、NO和PGE2的含量。结论:枳壳健胃颗粒对乙醇致大鼠胃粘膜损伤有明显的保护作用。

Objective： To study the protective effects of Zhiqiao Jianwei granules on gastric lesion in rats. Methods： Wistar rats were randomly divided into normal group,model group,Zhiqiao Jianwei granules（ 2. 7,5. 4,10. 8g /kg） group and ranitidine group. Zhiqiao Jianwei granules were used daily via lavage,once a day for 15 days. The gastric lesion model were induced by 75% ethanol. At the end of the experiment,the contents of SOD,MDA,NO and PGE2were detected,the ulcer index of gastric lesion were calculated and the pathology tissue were observed in rats. Results： Histopathological results showed Zhiqiao Jianwei granules can significantly improve the rat gastric mucosal hyperemia,edema and inflammatory infiltrates. Compared to the model group,Zhiqiao Jianwei granules（ 5. 4 g /kg,10. 8 g /kg） could significantly reduce the ulcer index and the content of MDA,and increase the contents of SOD,NO,PGE2. Conclusion： Zhiqiao Jianwei granules have the protective effects on gastric lesion in rats.