抗白酊治疗局限性白癜风及其对血清IL-2、IL-6、IL-10和TNF-α水平的影响

Treatment and its effect on serum levels of IL-2,IL-6,IL-10,and TNF-α of localized vitiligo by Kangbai Tincture

目的：观察抗白酊治疗局限性白癜风的临床疗效以及对IL-2、IL-6、IL-10和TNF-α水平的影响。方法：将68例患者随机分为抗白酊组（38例）和补骨脂酊组（30例）,另外随机抽取20名健康体检者,抗白酊组给予抗白酊,每日外搽1~2次,涂后日光照射5~10min,连用3个月观察疗效。补骨脂酊组用干净的棉签蘸取补骨脂酊涂抹于患处,每日1次,涂药后日光照射5-10min。所有观察者均进行血液流变学检测,应用放射免疫分析法检测白癜风患者治疗前后血清IL-2、IL-6、IL-10和TNF-α水平。结果：抗白酊组治疗前血液流变学多项指标高于健康组（P〈0.05）,治疗后各项指标均下降,且优于补骨酊组（P〈0.05）。局限性白癜风患者在治疗前血清IL-6（191.28±46.53,101.53±40.26）、IL-10（32.21±7.47,21.54±8.21）、TNF-α（2.12±1.28,0.94±0.25）水平非常显著地高于正常组（P〈0.01）,IL-2（1.39±0.11,4.03±1.22）水平非常显著地低于正常组（P〈0.01）;经治疗3个月后,抗白酊组可显著升高血清IL-2水平,降低IL-6、IL-10、TNF-α水平,与补骨脂酊组和正常组比较有显著性差异（P〈0.05）。抗白酊治疗后总有效率显著高于对照组（84.21%VS 43.33%,P〈0.05）。结论：抗白酊治疗局限性白癜风具有很好的临床疗效,其可能的机制为促进血液循环以及调节IL-2、IL-6、IL-10和TNF-α水平。

Objective： To observe therapeutic effect of Kangbai tincture on localized vitiligo and its impact on serum levels of IL-2,IL-6,IL-10,and TNF-α. Methods： 68 patients were randomly divided into Kangbai tincture group（ 38 cases） and the control Buguzhi tincture group（ 30 cases）,and randomly selected 20 healthy controls,Kangbai tincture group was given Kangbai tincture,1 ~ 2 times daily with external application,the sun exposure for 5 ~ 10 minutes. which to observe the curative effect after 3 months. Buguzhi tincture group was used a clean cotton swab dipped in tincture to apply on the affected area,1 times a day. and the sun exposure for 5 ~ 10 minutes. All patients were observed the curative effect after 3 months. All observes were detected the blood rheology and serum IL-2,IL-6,IL-10 and TNF-α levels before and after by radioimmunoassay. Results ： The indexes levels of hemorheology of the Kangbai tincture group was higher than those of normal group before treatment（ P ＆lt; 0. 05）,and decreased after treatment and is better than the control group（ P ＆lt; 0. 05）. Serum levels of IL-6（ 191. 28 ±46. 53,101. 53 ± 40. 26）,IL-10（ 32. 21 ± 7. 47,21. 54 ± 8. 21） 、TNF-α（ 2. 12 ± 1. 28,0. 94 ± 0. 25） in localized vitiligo patients before treatment were significantly higher than those of healthy people（ P ＆lt; 0. 01）,while IL-2（ 1. 39 ± 0. 11,4. 03 ± 1. 22） level was significantly lower than that of healthy people（ P ＆lt; 0. 01）. After treatment for 3 months,Kangbai tincture group can significantly elevated serum IL-2 level,decreased IL-6,IL-10,TNF-α level,there is significant difference compared with Buguzhi tincture group and the healthy group（ P＆lt; 0. 05）. The total effective rate was significantly higher than that of Buguzhi tincture group（ 76. 32% VS13. 33%,P ＆lt; 0. 05） by Kangbai Tincture therapy. Conclusion： Kangbai tincture treatment of localized vitiligo has good clinical efficacy,the mechanism for promoting blood circulation and regulation of IL-2,IL-6,IL-10 and TNF- α levels.