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真菌细胞壁病原相关分子模式TLR/Dectin-1通路及相关细胞因子的免疫作用 被引量：5

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摘要 侵袭性真菌感染(IFI)是致ICU患者死亡的重要原因之一。机体通过天然免疫重要的模式识别受体(PRR)Toll样受体(TLR)及C型凝集素受体(CLR)与病原相关分子模式(PAMP)识别后启动抗真菌免疫反应。目前明确磷脂甘露聚糖(PLM)的识别主要依赖TLR2和TLR4;β-葡聚糖经TLR2/树突状细胞相关性C型凝集素-1(Dectin-1)或只经Dectin-1识别。PLM和β-葡聚糖被识别后及经Dectin-1驱动获得性免疫后产生一系列下游细胞因子,一些下游细胞因子的免疫作用对不同组织有所不同、不确定或存在争议,一些免疫反应在细节上还没有详尽描述。因此,深入研究PAMP与PRR相互作用及其细胞因子对免疫调节影响,对IFI的预防治疗有重要意义。
作者 骆雪萍
机构地区 桂林医学院附属医院重症医学科
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2014年第8期892-895,共4页 Chinese Journal of Cellular and Molecular Immunology
基金 广西医疗卫生重点科研课题(重2012007) 广西自然科学基金(2013GXNSFAA019209)
关键词 真菌细胞壁病原相关分子模式 TLR Dectin-1通路 细胞因子 免疫作用 综述
分类号 R392.11 [医药卫生—免疫学] R379 [医药卫生—病原生物学]
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共引文献16

同被引文献61

  • 1刘日明,吴健民,高岩,潘世秀,李一荣,崔天盆.地塞米松对小鼠哮喘模型脾巨噬细胞TLR2和TLR4 mRNA表达的影响[J].中华微生物学和免疫学杂志,2005,25(9):742-746. 被引量：8
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细胞与分子免疫学杂志
2014年 第8期

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