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mRNA和microRNA在机械性窒息死推断中的研究进展 被引量：4

Advances in applicability of mRNA and microRNA to estimate the cause of mechanical asphyxia death
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摘要 机械性窒息死的推断是法医学鉴定的难点之一。利用实时荧光定量PCR(fluorogenic quantitative RT-PCR,RT-qPCR)技术检测RNA表达水平变化规律,并据之推测机械性窒息死亡的原因,近年来已成为研究热点。本文对mRNA和microRNA(miRNA或miR)在机械性窒息死推断的研究文献进行复习综述,并重点探讨miRNA在该类死因推断中的应用,以期为机械性窒息死推断提供新的思路。 Sometimes it is difficult in forensic science to estimate the cause of mechanical asphyxia death. The changes of RNA expression level detected by RT-qPCR could be used for the estimation,which has became a research focus recently. To provide novel perspectives for the future investigation,this review presents the advance of mRNA,and application of microRNA in particular,in deducing the cause of mechanical asphyxia death.
作者 潘晖 吕叶辉 张恒 陈龙
机构地区 复旦大学上海医学院法医学系
出处 《中国法医学杂志》 CSCD 2014年第2期121-123,共3页 Chinese Journal of Forensic Medicine
基金 国家自然科学基金资助项目(81172896) 国家自然科学基金资助项目(81373242)
关键词 法医病理学 机械性窒息 死亡原因 MICRORNA MIR-210 forensic pathology mechanical asphyxia cause of death microRNA miR-210
分类号 D919 [医药卫生—法医学]
  • 相关文献

参考文献20

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二级参考文献55

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共引文献59

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引证文献4

二级引证文献4

中国法医学杂志
2014年 第2期

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