眼眶朗格罕细胞组织细胞增生症临床病理分析

Clinicopathologic analysis of Langerhans cell histiocytosis

目的 探讨眼眶朗格罕细胞组织细胞增生症的组织病理学表现与临床诊治,提高对该病的认识.方法 收集2008年1月至2011年12月在河南省立眼科医院确诊的朗格罕细胞组织细胞增生症患者7例（7只眼）,对其临床诊治资料及组织病理学表现进行回顾性分析.结果 眼眶朗格罕细胞组织细胞增生症患儿共7例（7只眼）,其中男2例、女5例,平均年龄4.07岁.CT检查易发现溶骨性骨质破坏,组织病理学可发现典型的朗格罕细胞组织细胞,组织均伴有明显的出血.结论 眼眶朗格罕细胞组织细胞增生症多见于儿童,临床表现多样,病情轻重不一,对于某些患者必要时行手术活检病理检查,有利于诊断治疗.

Objective To investigate the clinical and pathological features of Langerhans cell histiocytosis （LCH）.Methods In this retrospective study,the clinical data and histopathological features of LCH patients treated in Henan Eye Hospital were collected and analyzed.Results There were 7 cases,including 2 males and 5 females.Mean age was 4.07 years old.Images of CT were easy to find osteolysis.Histopathology could find typical Langerhans cell.Tissues were accompanied by significant bleeding.Conclusions Because of its various clinical manifestations and prognosis,pathological biopsy is essential to some paediatric patients.