3Ohbayashi H.Matrix metalloproteinases in lung diseases.Curr Protein Pept Sci,2002,3(4):409-421.
4Zeiher BG,Matsuoka S,Kawabata K,et al.Neutrophilelastase and acute lung injury:prospects for sivelestat an other neutrophilelastase inhibitors as therapeutics.Criticalcare Medicine,2002,30(5Supp1):281-287.
5Shapiro SD,Ooldstein NM,Houghton AM,et al.Neutrophil-elastase contributes to cigarette smoke-induced emphysema in mice.Am J Pathol,2003,163:2329-2335.
6Reh G,Nerli B,Pico G.Isolation of alpha-1-antitrypsin from human plasma by partitioning in aqueous biphasic systems of polyethyleneglycol-phosphate.J Chromatography B,2002,780:389-396.
7Djie MZ,Stone SR,le Bonniec F.Intrinsic specificity of the reactive site loop of alphal-antitrypsin,alphal-antichymo tryp sin,antith rombin E,and protease nexin I.J Biol Chem,1997,272:16268.
8Novoradovskaya N,Lee JH,Yu ZX,et al.Inhibition of intracellular degradation increases secretion of a mutant form of alphal-antitrypsin associated with profound deficiency.J Clin Invest,1998,101:2693.
9Elliott PR,Abrahams JP,Lomas DA.Wild-type alphal-antitrypsin is in the canonical inhibitory conformation.J Moi Biol,1998,275(3):419.
10Piccioni PD,Kramps JA,Rudolphus A,et al.Proteinase/proteinase inhibitor imbalance in sputumsol phases from patients with chronic obsructive pulmonary disease.Chest,1992,102:1470-1476.
