肿瘤标记物单项检测和联合检测对肺癌的诊断价值

Observe and analyze the diagnositic value of tumor markers for lung cancer

目的探讨血清中肿瘤标记物CEA、CYFRA21-1、NSE和SCCAg进行单项和联合检测,对肺癌的诊断价值。方法选取行肿瘤标记物检测的肺癌患者80例,健康体检者80例,设为观察组和对照组;采用电化学发光免疫技术对其进行血清肿瘤标记物CEA、CYFRA21-1、NSE和SCCAg含量检测。结果观察组患者血清肿瘤标记物CEA、CYFRA21-1、NSE和SCCAg含量均高于对照组,差异统计学意义(P<0.05)。观察组CEA、CYFRA21-1、NSE和SCCAg阳性检测率分别为52.7%、67.4%、63.5%、31.9%;血清四项肿瘤标记物联合检测的阳性率为89.3%,对肺癌诊断灵敏度明显优于单项检测(P<0.05);进行联合检测时对腺癌的检出率为71.4%,小细胞癌为75.0%,鳞状细胞癌为90.2%,均明显高于肿瘤标记物各项单项检出率。结论肿瘤标记物CEA、CYFRA21-1、NSE和SCCAg联合检测阳性检出率明显高于单项检测,更有利于肺癌的诊断。

Objective To analyze and explore the diagnositic value and clinical effect of lung cancer through single detection and combined detection.Methods 80 cases of lung cancer patients and 80 cases of healthy patients who did tumor markers detection in our hospital from January,2012 to January,2013 were analyzed retrospectively,divided them into experimental group and control group.The content of serum tumor markers were CEA,CYFRA21 -1, NSE and SCCAg by electrochemiluminescence immunoassay.Results The serum tumor markers CEA,CYFRA21 -1 ,NSE and SCCAg of experimental group was higher than control group,the difference has statistic significance（P〈0.05）.The tumor markers of experimental group was more sensitive to the diagnosis of lung cancer,the positive detection rates of CEA,CYFRA21 -1,NSE and SCCAg were 52.7%、67.4%、63.5%、31.9%;the positive rate of four serum tumor markers combined detection was 89.3%,the diagnosis sensitivity of lung cancer was significantly better than single detection（P〈0.05）;the detection rate of combined detection for cancer was 71.4%,for small cell carcinoma was 75.0%,squamous cell carcinoma was 90.2%,which were significantly higher than those of the single tumor markers detection rate.Conclusion The positive rate of combined tumor markers CEA,CYFRA21 -1,NSE and SCCAg detection is significantly higher than that of single detection,which is more conductive to timely diagnosis of lung cancer,to identify pathological type of lung cancer.