髓母细胞瘤SHH信号通路及靶向抑制剂研究进展

Research progress of Sonic Hedgehog signaling pathway and its targeted inhibitors in medulloblastoma

SHH信号通路在小脑的发育形成过程中发挥着重要作用,能够调控小脑细胞正常发育周期及细胞增殖,维持小脑正常的功能和结构。SHH信号通路异常激活会出现小脑细胞异常增殖而导致髓母细胞瘤(MB)发生,是MB形成过程中最具有特异性的通路之一。针对SHH信号通路靶向抑制剂治疗将成为治疗MB的新方法,能特异性地阻断特定信号转导途径,靶向于肿瘤细胞的微环境及分子表达从而抑制肿瘤生长和转移。本文就MB发病机制中的SHH信号通路和基于该信号通路靶向抑制剂的研究进展作一综述。

Sonic Hedgehog （SHH） signaling pathway plays an important role in the formation process in the development of the cerebellum. It can regulate the normal development of the cerebellum cell cycle and cell proliferation to maintain normal function and structure of the cerebellum. Aberrant SHH signaling pathway causes severe cerebellar development and medulloblastoma （MB）. Targeted for SHH signaling pathway inhibitor treatment will become a new treatment for MB, specificity to block certain signal transduction pathways, targeted to the microenvironment of tumor cells and molecules expression to inhibit tumor growth and metastasis. This review summarized the research progress of SHH signaling pathway and its targeted inhibitors in MB.