葡萄糖酸锌结合山莨菪碱治疗小儿轮状病毒性肠炎的临床效果观察

Clinical Effect Observation of Zinc Gluconate Combined with Anisodamine in Treatment of Children with Rotavirus Enteritis

目的:观察葡萄糖酸锌结合山莨菪碱治疗小儿轮状病毒性肠炎的临床效果,探究其联合应用价值。方法:选取2012年10月-2013年1月本科收治的70例确诊为小儿轮状病毒肠炎的患儿,按照随机数字表法将其分为对照组和试验组各35例,对照组给予常规治疗,试验组在其基础上给予葡萄糖酸锌结合山莨菪碱进行治疗,观察比较两组治疗效果、病毒转阴率和平均病程时间。结果:试验组的总有效率94.3%明显高于对照组的74.3%,病毒转阴率68.6%明显高于对照组的42.9%,差异均有统计学意义(P<0.05),且试验组的平均病程(3.48±0.75)d明显短于对照组的(5.24±0.93)d,差异有统计学意义(P<0.001)。结论:葡萄糖酸锌结合山莨菪碱治疗小儿轮状病毒性肠炎的治疗效果比常规的方案更加有效,并且可以缩短病程,提高治愈率,降低患儿并发症的发生,值得临床推广。

Objective：To observe the clinical effect of zinc gluconate combined with anisodamine in treatment of children with rotavirus enteritis,and explore its combined application value.Method：70 children diagnosed as rotavirus enteritis in our department from October 2012 to January 2013 were selected,they were randomly divided into the control group and the experimental group according to the random number table method,35 cases in each group.The control group was given conventional therapy,the experimental group was given zinc gluconate combined with anisodamine on the basis of the control group.The effect of treatment,the virus clearance rate and average duration between the two groups were observed and compared.Result：The total efficiency of experimental group was 94.3%,it was significantly higher than 74.3%of the control group,the virus clearance rate of experimental group was 68.6%,it was significantly higher than 42.9%of the control group,the differences were statistically significant（P〈0.05）.And the average duration of experimental group was（3.48±0.75）d,it was significantly shorter than（5.24±0.93）d of the control group,the difference was statistically significant（P〈0.001）.Conclusion：The treatment effect of Zinc gluconate combined with anisodamine in treatment of children with rotavirus enteritis is more effective than the conventional scheme,and can shorten the course of disease,improve the cure rate,reduce the incidence of complications,is worthy of clinical promotion.