多发性硬化和视神经脊髓炎的体液免疫机制及其干预策略

The role of humoral autoimmunity in multiple sclerosis and neuromyelitis optica and therapeutic strategy

多发性硬化(multiple sclerosis,MS)和视神经脊髓炎(neuromyeltis optica,NMO)是两个独立的中枢神经系统炎性脱髓鞘疾病,B细胞和体液免疫在二者发生发展中发挥了重要作用。越来越多证据显示,针对B细胞和/或抗体的治疗有可能同时对抗MS和NMO。就B细胞及其体液免疫在MS和NMO发生发展及治疗中的作用做一综述。

Multiple sclerosis （MS） and neuromyelitis optica （NMO） are two different inflammatory demyelinating diseases in central nervous system. B cells and humoral immune responses play an important role in the immunopathogenesis of MS and NMO. There is growing evidence that treatments specifically targeting B cells and/ or antibodies are effective in both MS and NMO. This review therefore aims to summarize the present knowledge and to outline future directions about the role of B cells and antibodies in research and therapy of MS and NMO.