羊水、胎皮与脐血对创伤愈合的影响

Effect of Different Constituents of Fetal Lamb on Adult Wound Healing

为促进伤口以完全再生的方式无瘢痕或较少瘢痕愈合 ,在实验羊背部脊椎两侧制做伤口模型 ,用羊水、胎皮、脐血等不同成分对伤口进行治疗 ,并于治疗后 1、3、7、1 4d取材 ,分别做HE、马宋三色染色 ,7d组做电镜切片 ,观察疗效。结果 :同期内羊水组、胎皮组及脐血组比云南白药组及生理盐水组炎症清除反应及肉芽、胶原生长好 ,但未发现有明显减少瘢痕愈合的作用。结果提示 :胎羊不同组分 (羊水、胎皮、脐血 )可促进伤口愈合 ,缩短愈合时间。

Different constituents of fetal lamb were used to induce scarless wound healing.Sheep wound models were prepared on both sides of vertebral column. Amniotic fluid, fetal skin and cord blood were picked up from pregnant sheep. Total protein amounts of different constituents were examined. Different constituents of fetal lamb were used to treat adult sheep wounds. To investigate the repair, compared the wound healing of 1 d, 3 d, 7 d and 14 d in the adult sheep during different treatments in HE and Masson staining. Electronic microscope observation was done in 7 d wounds. Results: During the same period, clean inflammation reaction, granulation tissue and collagen desposition are better in amniotic fluid group, fetal skin group and cord blood group than in Yunnan bai yao group and N.S group. But didn't find the scarless wound healing in those groups. Conclusion: The different constituents of fetal lamb may improve the wound repair in adult sheep and make wound healing in a shorter time.