长链非编码RNA在癌症中的研究进展

Progress of long noncoding RNA in cancer

长链非编码RNA(long noncodirg RNA,IncRNA)是一类转录本长度超过200个核苷酸的非编码RNA,通常不编码蛋白质。随着研究的进展,人们发现lncRNA来源复杂、功能各异,在表观遗传学、转录水平、转录后水平等多个水平发挥着重要的作用。笔者旨在介绍IncRNA的来源及生物学功能,并着重阐述其在癌症生物学中的研究进展。

Long noncoding RNA （lncRNA） is defined as transcripts longer than 200 nucleotides （nt） with little or no protein-coding capacity. It was found that lncRNA was originated in complicated sources, and played different functions in multiple levels such as epigenetic, transcriptional and post-transcriptional regulation levels. Here we briefly summarize the origin and biological function of lncRNA, and emphatically focus on the progress in cancer biology.