摘要
长链非编码RNA(long noncodirg RNA,IncRNA)是一类转录本长度超过200个核苷酸的非编码RNA,通常不编码蛋白质。随着研究的进展,人们发现lncRNA来源复杂、功能各异,在表观遗传学、转录水平、转录后水平等多个水平发挥着重要的作用。笔者旨在介绍IncRNA的来源及生物学功能,并着重阐述其在癌症生物学中的研究进展。
Long noncoding RNA (lncRNA) is defined as transcripts longer than 200 nucleotides (nt) with little or no protein-coding capacity. It was found that lncRNA was originated in complicated sources, and played different functions in multiple levels such as epigenetic, transcriptional and post-transcriptional regulation levels. Here we briefly summarize the origin and biological function of lncRNA, and emphatically focus on the progress in cancer biology.
出处
《自然杂志》
北大核心
2014年第3期192-201,共10页
Chinese Journal of Nature
基金
国家自然科学基金项目(31170750)资助
关键词
lncRNA
癌症
转录后调控
IncRNA, cancer, post-transcriptional regulation