小鼠颈动脉血栓模型的建立

Establishment of thrombosis model in carotid artery of mouse

目的：探讨并建立颈动脉血栓模型。方法：采用FeCl3致颈动脉损伤，造成血栓形成，激光多普勒记录血栓形成曲线，HE染色观察血栓形态。结果：10％FeCl3损伤后，约137～366S形成稳定血栓。结论：利用此方法所造颈动脉血栓模型操作简单，成功率高，适用于抗血栓药物筛选。

Objective： To establish a model of carotid artery thrombosis. Methods： The application of FeCI3 injured the carotid artery, which induced the thrombosis. The thrombosis curve was recorded by laser-doppler, and its morphological changer were observed by HE staining. Results： The thrombus was formed 137-366 seconds after the carotid artery was injured by 10% FeCl3. Conclusion： The method is simple and easy,which is suitable for the screening of antithrombotic agents.