肾间质纤维化发生机制研究进展

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摘要肾间质纤维化（interstitial fibrosis，RIF）是指由各种损伤因素引起的肾脏病理过程，组织学表现为肾间质内的成纤维细胞显著增生和细胞外基质的过度沉积。RID是慢性肾病的终末阶段，预后很差；因此，深入了解RID的形成机制，对指导其防治具有重要意义。长期以来，肾小管上皮细胞-间叶细胞转分化（epithelial—mesenchymaltransition，EMT）被认为是RIF的重要原因，不过新近有学者提出不同观点，认为EMT与肾间质纤维化无关，而是与周细胞-间叶细胞转分化以及间质微血管稀疏化密切相关，本文将就此作一综述。

作者王丽马跃荣

机构地区泸州医学院病理学教研室

出处《泸州医学院学报》 2014年第3期339-341,共3页 Journal of Luzhou Medical College

关键词肾间质纤维化 EMT RIF

分类号 R363.21 [医药卫生—病理学]

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