小儿闭合性颅脑损伤血清和脑脊液中β-EP含量、红细胞免疫功能的变化

Levels of beta-endorphine in serum and cerebrospinal fluid and changes in erythrocyte immunological function in children with closed craniocerebral injury

目的：研究小儿闭合性颅脑损伤血清和脑脊液中β-内啡肽(β-EP)含量及红细胞免疫功能的变化。方法：选择46例闭合性颅脑损伤患儿(观察组)和30例同年龄组非神经系统疾病患儿(对照组)，分别测定他们的血清和脑脊液中β-EP含量及红细胞粘附肿瘤花环率。结果：观察组血清和脑脊液中β-EP含量较对照组明显升高，红细胞粘附肿瘤花环率则明显下降，而且病情越重，β-EP升高、红细胞粘附肿瘤花环率下降的越明显。结论：β-EP对红细胞免疫功能具有双重调节作用，且β-EP和红细胞免疫功能二者与病情相关。

Objective: To study the levels of beta-endorphine(β-EP) in serum and cerebrospinal fluid and the changes in erythrocyte immunological function in closed craniocerebral injury children. Methods: Observation group (46 closed craniocerebral injury children) and control group (30 age-matched children with no nervous system diseases) were selected. The levels of beta-endorphine in serum and cerebrospinal fluid and the rate of erythrocyte natural adhesion to tumor cell were determined. Results: Compared with the control group, the levels of β-EP in serum and cerebrospinal fluid obviously rose and the rate of erythrocyte natural adhesion to tumor cell obviously fell in observation group. What is more, the more severe the condition of disease was, the higher the levels of β-EP in serum and cerebrospinal fluid were, and the lower the rate of erythrocyte natural adhesion to tumor cell was. Conclusion: Beta-endorphine has the dual regulation of erythrocyte immunological function, and both of them correlate with the disease condition.