2,5-二吡啶基-1,3,4-噁二唑的合成

Synthesis of 2,5-Dipyridyl-1,3,4-oxadiazoles

以烟酸/异烟酸为原料,经由酰化、肼解、关环三步反应合成了2,5-二吡啶基-1,3,4-噁二唑,每步收率均在80%以上。该合成路线原料易得,实验条件温和,操作简单等优点,是实验室制备2,5-二吡啶基-1,3,4-噁二唑的一种简便可行的方法。

2,5-dipyridyl-1,3,4-oxadiazoles were synthesized from nicotinic acid/ isonicotinic acid through acylation, hydra-zine decomposition and ring-closing reaction, and each step yields were above 80% . This method has such advantages as mild reac-tion conditions, simplified operational procedure and easiness in getting the raw materials. What’s more, it can be carried out under mild conditions applicable for the productions in the laboratory.