卵巢上皮癌组织中LRP和P-gp表达及其临床意义

Expression of Lung Resistance Protein and P glycoprotein and Clinical Significance in Epithelial Ovarian Tumor

目的 探讨卵巢上皮癌组织中肺耐药蛋白 (lungresistanceprotein ,LRP)表达的临床意义。 方法 采用免疫组化S P法对 79例卵巢上皮性肿瘤 (恶性 5 4例、交界性 5例、良性 2 0例 )和 18例正常卵巢组织进行LRP和P gp表达检测 ,并进行相关临床因素分析。结果 LRP在正常卵巢组织、良性、交界性和恶性卵巢上皮性肿瘤组织中的表达阳性率分别为 38.9%、30 .0 %、80 .0 %和 75 .9%。LRP的表达与卵巢癌病理组织类型、腹腔积液相关。化疗对LRP表达阳性和阴性卵巢上皮癌患者的有效率分别为 5 0 .0 %和 84.6 % ,有显著性差异 (P <0 .0 5 )。LRP表达阴性患者的预后优于阳性者 (P <0 .0 5 )。LRP与P gp表达无相关性 ,两者可协同表达。

Objective To explore the clinical significance of lung resistance protein(LRP) in ovarian epithelial tumors.Methods The expressions of LRP and P gp were examined by immunochemical method in 54 ovarian epithelial carcinomas,15 borderline tumors,20 benign tumors and 18 normal ovarian tissues.The relationship between the expression of LRP and clinical pathologic features,resistance to chemotherapy and prognosis and also its correlation to P gp were analyzed.Results The positive rates of LRP and P gp in normal ovarian tissues、benign、borderline and malignant epithelial ovarian tumors were 38.9%、30.0%、80.0% and 75.9% respectively.The expression of LRP was associated with presence of ascites and histologic type.The response rate to chemotherapy in patients with positive LRP and negative LRP was 50.0% and 84.6% respectively( P <0.05).The LRP positive patients were poorer in prognosis than negative one( P <0.05).The expression of LRP had no correlation with P gp.Conclusion LRP expression in ovarian epithelial carcinoma is related to drug resistance and it is an useful prognostic marker.