摘要
糖皮质激素(glucocorticoid.GC)在临床应用广泛,其主要的副作用之一是对骨的影响,导致糖皮质激素性骨质疏松(glucocorticoid induced osteoporosis.GIOP)的风险显著增加。目前研究认为其机制为:糖皮质激素通过调高细胞外因子DKK1、SFRPs的表达水平抑制Wnt/β-catenin信号通路,从而抑制骨细胞形成;通过增强成骨负性因子SOST、PPARγ2的活性,弱化成骨活性因子Cbfal、IGF-1的表达来抑制骨形成。同时通过调节OPG/RANKL/RANK途径促进骨吸收。本文从糖皮质激素对骨形成和骨吸收两个方面的影响对糖皮质激素性骨质疏松的发生机制进行探讨,综述了近几年国内外对糖皮质激素性骨质疏松的研究现状,以此为该疾病的治疗提供相关理论帮助。
Glucocorticoids （glucocorticoid.GC） are widely used in clinic, one of the main side effects are effects on bone, glucocor-ticoid induced osteoporosis （glucocorticoid induced osteoporosis.GIOP） significantly increased the risk of. Glucocorticoid inhibition of Wnt/ β -catenin pathway through the adjustable high expression levels of cytokines DKK1, SFRPs, thereby inhibiting bone for-mation by enhancing cell; Osteogenic negative factor SOST, PPAR γ 2 activity, weakening the expression of osteogenic activity of factor Cbfal, IGF-1 to inhibit bone formation. At the same time, by regulating the OPG/RANKL/RANK pathway promotes bone re-sorption. This article carries on the discussion from the GC formation and bone resorption on two aspects of the mechanism of GIOP on bon,which is to provide the theoretical help for the treatment of diseases.
出处
《中国卫生产业》
2014年第15期189-190,192,共3页
China Health Industry
基金
国家自然科学基金地区科学基金项目
项目批准号(81260285)
