血必净治疗急性胰腺炎的临床疗效及对血清炎症因子和氧自由基的影响

Clinical therapeutic effects of Xuebijing on acute pancreatitis and the effects on serum inflammatory factors and oxygen radicals

目的探讨血必净治疗急性胰腺炎的临床疗效,以及对患者血清超敏C反应蛋白(hs-CRP)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)及丙二醛(MDA)、超氧化物歧化酶(SOD)水平的影响。方法选取符合标准的患者80例,随机分为观察组和对照组各40例,均给予常规治疗,观察组在此基础上加用血必净注射液,观察两组的临床疗效,以及血清炎症因子(hs-CRP、IL-8、TNF-α)和氧自由基(MDA、SOD)水平变化。结果两组患者入院时血清炎症因子(hs-CRP、IL-8及TNF-α)及氧自由基(MDA、SOD)水平相似,差异无统计学意义(P>0.05);治疗7 d后,两组血清炎症因子(hs-CRP、IL-8及TNF-α)及MDA水平均下降,SOD均上升,但是观察组改善幅度较对照组更显著,差异均有统计学意义(P<0.05)。观察组总有效率80.00%,明显高于对照组的62.50%,差异有统计学意义(P<0.05)。结论血必净治疗急性胰腺炎,可有效降低患者血清炎症因子,清除氧自由基,提高临床治疗效果,具有一定的临床应用价值。

Objective To investigate the clinical therapeutic effects of Xuebijing （Chinese formulated product） on acute pancreatitis and the effects on serum hypersensitive C reactive protein （hs-CRP）, interleukin-8 （IL-8）, tumor necrosis factor-α （TNF-α）, mal-ondialdehyde （MDA）, and superoxide dismutase （SOD） levels in the patients. Methods 80 eligible patients were selected and ran-domly divided into observation group and control group, 40 patients each group. Both groups were given with routine therapies, the observation given with Xuebijing Injection additionally, and the clinical therapeutic effects and changes in the serum inflammatory factors （hs-CRP, IL-8 and TNF-α） and oxygen radicals （MDA and SOD） levels of the two groups were observed. Results The serum inflammatory factors （hs-CRP, IL-8 and TNF-α） and oxygen radicals （MDA and SOD） levels in the patients of the two groups when admission were similar, and the differences were statistically insignificant （P〉0.05）; in 7d after the therapies, the serum inflammatory factors （hs-CRP, IL-8 and TNF-α） and MDA levels in the patients of both groups were decreased, and SOD levels in the patients of both groups were increased, but the improvement extent of the observation group was greater than that of the control group, and all the differences were statistically significant （P〈0.05）. The total effective rate of the observation group was 80.00%, significantly higher than that of the control group （62.50%）, and the difference was statistically significant （P〈0.05）. Con-clusion In patients with acute pancreatitis, Xuebijing can effectively decrease serum inflammatory factors, eliminate oxygen radi-cals and elevate clinical therapeutic effects, and consequently has positive clinical application values.