多发性骨髓瘤骨病发生机制及诊疗研究进展

Research progress on the pathogenesis,diagnosis and treatment of multiple myeloma bone disease

多发性骨髓瘤骨病(MBD)以全身骨质破坏亢进和新骨生成受抑为主要特征,临床表现为骨痛、骨质疏松、病理性骨折以及相关神经压迫症状等。MBD是多发性骨髓瘤(MM)最常见的并发症之一,其发病隐匿,误诊率较高,患者的生存质量及预后较差。该文通过对其发病机制及诊疗进展进行综述,为临床治疗MBD提供参考。

The main features of multiple myeloma bone disease （ MBD） are hyperactivity of systemic bone de-struction and inhibition of new bone formation .Its clinical manifestations include pain , osteoporosis , pathologic frac-tures and associated nerve compression symptoms etc .MBD is one of the most common complications of multiple mye-loma（ MM） .Its occurrence is occult with higher misdiagnosis rate and patients′quality of life and prognosis are poor . In this article , its pathogenesis ,diagnosis and treatment are reviewed , in order to provide reference for clinical treat-ment of MBD .