塞利洛尔与阿替洛尔治疗高血压的对照研究

The Parallel Comparative Trial of Celiprolol and Atenolol Monotherapy in Patients with Essential Hypertension

目的观察塞利洛尔治疗原发性高血压的降压疗效并与阿替洛尔进行比较。 方法采用多中心、随机、双盲、平行对照法 ,入选 2 1～ 60岁血压为 ( 160～ 2 0 0 )mmHg/ ( 95 ～ 114 )mmHg( 1mmHg =0 .13 3kPa)的原发性高血压病人 2 4 0例进行 8周的观察 ,随机服用塞利洛尔 10 0～ 4 0 0mg/d或阿替洛尔 2 5 ～ 10 0mg/d。 结果塞利洛尔组 ( 114例 )血压从 ( 163 .9± 2 0 .3 )mmHg/ ( 10 5± 11.3 )mmHg降至 ( 13 9.1± 17.2 )mmHg/ ( 86.0± 7.3 )mmHg ;阿替洛尔组 ( 112例 )血压从 ( 164.5± 2 0 .0 )mmHg/ ( 10 4 .0± 8.1)mmHg降至 ( 13 8.2± 17.4 )mmHg/ ( 84 .2± 8.3 )mmHg。控制 2 4h血压 ,塞利洛尔较阿替洛尔为佳。 结论 β 受体阻滞剂塞利洛尔是一种有效而安全的降压药 ,比阿替洛尔有更好的控制 2 4h血压的作用 ,推荐剂量为 10 0～ 3 0 0mg/d。

Objective To observe the antihypertensive efficacy of celiprolol in patients with essential hypertension and compare with that of atenolol. The study was a multicentre, randomized, double blind, parallel trial of 8 weeks' duration conducted at three medical centers in China. Men and women aged 21 ～ 60 years with baseline blood pressure at (160 ～ 200)mmHg/(95 ～ 114)mmHg (1mmHg=0.133kPa) were included in the study, and randomly allocated to receive either celiprolol or atenolol. The doses were 100 ～ 400mg/d for celiprolol and 25 ～ 100mg/d for atenolol. Systolic and diastolic blood pressure decreased significantly from the baseline in both groups (P<0.0001). The blood pressure was reduced from (163.9±20.3)mmHg/(105.1±11.3)mmHg to(139.1±17.2)mmHg/(86.0±7.3)mmHg in the celiprolol group and from (164.5±20.0)mmHg/(104.0±8.1)mmHg to (138.2±17.4)mmHg/(84.2±8.3)mmHg in the atenolol group. Better control of 24h blood pressure was observed in the celiprolol group. β blocker celiprolol is an effective and safe antihypertensive drug. It has better 24h blood pressure control than atenolol. The recommended dosage is 100 ～ 300mg once a day with morning.